关于I型和II型脱氢奎尼酸酶与(6R)-和(6S)-6-氟-3-脱氢奎尼酸的机制研究。
Mechanistic studies on type I and type II dehydroquinase with (6R)- and (6S)-6-fluoro-3-dehydroquinic acids.
作者信息
Parker E J, González Bello C, Coggins J R, Hawkins A R, Abell C
机构信息
University Chemical Laboratory, Cambridge, UK.
出版信息
Bioorg Med Chem Lett. 2000 Feb 7;10(3):231-4. doi: 10.1016/s0960-894x(99)00660-5.
Abstract
(6R)- and (6S)-6-Fluoro-3-dehydroquinic acids are shown to be substrates for type I and type II dehydroquinases. Their differential reactivity provides insight into details of the reaction mechanism and enables a novel enzyme-substrate imine to be trapped on the type I enzyme.
摘要
(6R)-和(6S)-6-氟-3-脱氢奎尼酸被证明是I型和II型脱氢奎尼酸酶的底物。它们的不同反应性有助于深入了解反应机制的细节，并能捕获一种新型的酶-底物亚胺到I型酶上。
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