Morgan U, Weber R, Xiao L, Sulaiman I, Thompson R C, Ndiritu W, Lal A, Moore A, Deplazes P
World Health Organisation Collaborating Centre for the Molecular Epidemiology of Parasitic Infections and State Agricultural Biotechnology Centre, Murdoch University, Murdoch, WA 6150, Australia.
J Clin Microbiol. 2000 Mar;38(3):1180-3. doi: 10.1128/JCM.38.3.1180-1183.2000.
A total of 22 Cryptosporidium isolates from human immunodeficiency virus-infected patients from Kenya, Switzerland, and the United States were examined at three genetic loci: the 18S ribosomal DNA, HSP-70, and acetyl coenzyme A synthetase genes. Four distinct Cryptosporidium genotypes were identified: (i) the Cryptosporidium parvum "human" genotype, (ii) the C. parvum "cattle" genotype, (iii) Cryptosporidium felis, and (iv) Cryptosporidium meleagridis. This is the first report of C. meleagridis in a human host. These results and those of others indicate that immunocompromised individuals are susceptible to a wide range of Cryptosporidium species and genotypes. Future studies are required to understand the full public health significance of Cryptosporidium genotypes and species in immunocompromised hosts.
对来自肯尼亚、瑞士和美国的22株从感染人类免疫缺陷病毒的患者体内分离出的隐孢子虫，在三个基因位点进行了检测：18S核糖体DNA、热休克蛋白70（HSP-70）和乙酰辅酶A合成酶基因。鉴定出四种不同的隐孢子虫基因型：（i）微小隐孢子虫“人”基因型，（ii）微小隐孢子虫“牛”基因型，（iii）猫隐孢子虫，以及（iv）火鸡隐孢子虫。这是火鸡隐孢子虫在人类宿主中的首次报告。这些结果以及其他研究结果表明，免疫功能低下的个体易感染多种隐孢子虫物种和基因型。需要进一步开展研究，以了解隐孢子虫基因型和物种在免疫功能低下宿主中的全部公共卫生意义。
