Prendiville S, Burman K D, Ringel M D, Shmookler B M, Deeb Z E, Wolfe K, Azumi N, Wartofsky L, Sessions R B
Departments of Otolaryngology-Head and Neck Surgery and Pathology, Georgetown University Hospital, Washington, DC 20007, USA.
Otolaryngol Head Neck Surg. 2000 Mar;122(3):352-7. doi: 10.1016/S0194-5998(00)70047-7.
Twenty-four cases of the tall cell variant (TCV), a subset of papillary thyroid carcinoma, were identified in a group of 624 patients with thyroid cancer. All pathology specimens were reviewed, and each patient's carcinoma was categorized according to characteristics on presentation, local recurrence, distant metastases, follow-up, and tumor-related mortality. The TCV group was compared with a historical control group (Mazzaferri and Jhiang: 1355 patients). The TCV group had a statistically higher percentage of stage 3 and 4 carcinoma, extrathyroidal invasion, and tumor size less than 1.5 cm than the control group. There was no statistical relationship between age greater than 50 years and stage in the TCV group. No relationship could be found between TCV histology and recurrence or mortality. These findings, combined with those of studies that link stage on presentation to poor outcomes, have led to our conclusion that TCV is an aggressive malignancy warranting appropriate treatment and close follow-up.
在一组624例甲状腺癌患者中，确诊了24例高细胞变体（TCV），它是乳头状甲状腺癌的一个亚型。对所有病理标本进行了复查，并根据患者癌症的临床表现、局部复发、远处转移、随访情况及肿瘤相关死亡率等特征进行分类。将TCV组与一个历史对照组（Mazzaferri和Jhiang：1355例患者）进行比较。与对照组相比，TCV组中3期和4期癌、甲状腺外侵犯以及肿瘤大小小于1.5 cm的比例在统计学上更高。在TCV组中，年龄大于50岁与分期之间无统计学关联。未发现TCV组织学与复发或死亡率之间存在关联。这些发现，再结合那些将临床表现分期与不良预后联系起来的研究结果，使我们得出结论：TCV是一种侵袭性恶性肿瘤，需要进行适当治疗并密切随访。
