无翅靶基因Dfz3编码果蝇卷曲蛋白家族的一个新成员。

The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family.

作者信息

Sivasankaran R, Calleja M, Morata G, Basler K

机构信息

Institut für Molekularbiologie, Universität Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland.

出版信息

Mech Dev. 2000 Mar 1;91(1-2):427-31. doi: 10.1016/s0925-4773(99)00313-5.

DOI:10.1016/s0925-4773(99)00313-5

PMID:10704878

Abstract

Here we report the identification of Dfz3, a novel member of the Frizzled family of seven-pass transmembrane receptors. Like Dfz2, Dfz3 is a target gene of Wingless (Wg) signalling, but in contrast to Dfz2, it is activated rather than repressed by Wg signalling in imaginal discs. We show that Dfz3 is not required for viability but is necessary for optimal Wg signalling at the wing margin.

摘要

在此，我们报告了Dfz3的鉴定结果，它是七次跨膜受体卷曲蛋白家族的一个新成员。与Dfz2一样，Dfz3是无翅（Wg）信号通路的一个靶基因，但与Dfz2不同的是，在成虫盘（imaginal discs）中它被Wg信号通路激活而非抑制。我们发现Dfz3对于生存能力并非必需，但对于翅缘的最佳Wg信号传导是必要的。