Tian Ai, Benchabane Hassina, Ahmed Yashi
Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
J Dev Biol. 2018 Mar 28;6(2):8. doi: 10.3390/jdb6020008.
In mammals, the Wnt/β-catenin signal transduction pathway regulates intestinal stem cell maintenance and proliferation, whereas Wnt pathway hyperactivation, resulting primarily from the inactivation of the tumor suppressor Adenomatous polyposis coli (APC), triggers the development of the vast majority of colorectal cancers. The Drosophila adult gut has recently emerged as a powerful model to elucidate the mechanisms by which Wingless/Wnt signaling regulates intestinal development, homeostasis, regeneration, and tumorigenesis. Herein, we review recent insights on the roles of Wnt signaling in Drosophila intestinal physiology and pathology.
在哺乳动物中，Wnt/β-连环蛋白信号转导通路调节肠道干细胞的维持和增殖，而主要由肿瘤抑制因子腺瘤性息肉病基因（APC）失活导致的Wnt通路过度激活会引发绝大多数结直肠癌的发生。果蝇成虫肠道最近已成为一种强大的模型，用于阐明无翅型/翼状螺旋转录因子（Wingless/Wnt）信号传导调节肠道发育、稳态、再生和肿瘤发生的机制。在此，我们综述了关于Wnt信号在果蝇肠道生理和病理中的作用的最新见解。
