缺乏β干扰素的小鼠抗病毒反应受损及α/β干扰素诱导异常。
Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon.
作者信息
Deonarain R, Alcamí A, Alexiou M, Dallman M J, Gewert D R, Porter A C
机构信息
MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London W12 ONN, United Kingdom.
出版信息
J Virol. 2000 Apr;74(7):3404-9. doi: 10.1128/jvi.74.7.3404-3409.2000.
Abstract
We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.
摘要
我们培育出了缺乏β干扰素基因的小鼠，并报告称它们对痘苗病毒感染高度敏感。此外，在培养的胚胎成纤维细胞中，病毒对α干扰素和2-5A合成酶基因的诱导作用受损。我们还表明，β干扰素不会启动自身的表达。
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