Klein V, Chajès V, Germain E, Schulgen G, Pinault M, Malvy D, Lefrancq T, Fignon A, Le Floch O, Lhuillery C, Bougnoux P
Laboratoire de Biologie des Tumeurs, d'anatomo-pathologie, Clinique d'Oncologie-Radiothérapie, Service de Gynécologie-Obstétrique, E. A. 2103, Unité de Recherche Associée Université-INRA, CHU, Tours, France.
Eur J Cancer. 2000 Feb;36(3):335-40. doi: 10.1016/s0959-8049(99)00254-3.
Data derived from experimental studies suggest that alpha-linolenic acid may have a protective effect in breast cancer. Observations obtained from epidemiological studies have not allowed conclusions to be drawn about a potential protective effect of dietary alpha-linolenic acid on breast cancer, possibly because of methodological issues. This case-control study conducted in an homogeneous population from a central area in France was designed to explore the hypothesis that alpha-linolenic acid inhibits breast cancer, using fatty acid levels in adipose breast tissue as a biomarker of past qualitative dietary intake of fatty acids. Biopsies of adipose breast tissue at the time of diagnosis were obtained from 123 women with invasive non-metastatic breast carcinoma. 59 women with benign breast disease served as controls. Individual fatty acids were analysed by capillary gas chromatography. An unconditional logistic regression model was used to obtain odds ratio estimates whilst adjusting for age, menopausal status and body mass index (BMI). No association was found between fatty acids (saturates, monounsaturates, long-chain polyunsaturates n-6 or n-3) and the disease, except for alpha-linolenic acid which showed an inverse association with the risk of breast cancer. The relative risk of breast cancer for women in the highest quartile of adipose breast tissue alpha-linolenic acid level was 0.36 (95% confidence interval=0.12-1.02) compared with those in the lowest quartile (P trend=0.026), suggesting a protective effect of alpha-linolenic acid in the risk of breast cancer. The effects of dietary alpha-linolenic on the risk of breast cancer warrant further study.
来自实验研究的数据表明,α-亚麻酸可能对乳腺癌具有保护作用。从流行病学研究中获得的观察结果尚未得出关于膳食α-亚麻酸对乳腺癌潜在保护作用的结论,这可能是由于方法学问题。在法国中部一个同质人群中进行的这项病例对照研究旨在探讨α-亚麻酸抑制乳腺癌的假设,使用乳腺脂肪组织中的脂肪酸水平作为过去脂肪酸定性饮食摄入量的生物标志物。在诊断时从123例浸润性非转移性乳腺癌女性中获取乳腺脂肪组织活检样本。59例患有良性乳腺疾病的女性作为对照。通过毛细管气相色谱法分析个体脂肪酸。使用无条件逻辑回归模型在调整年龄、绝经状态和体重指数(BMI)的同时获得比值比估计值。除α-亚麻酸与乳腺癌风险呈负相关外,未发现脂肪酸(饱和脂肪酸、单不饱和脂肪酸、长链多不饱和脂肪酸n-6或n-3)与疾病之间存在关联。乳腺脂肪组织α-亚麻酸水平处于最高四分位数的女性患乳腺癌相对风险为0.36(95%置信区间=0.12 - 1.02),而最低四分位数的女性为1(P趋势=0.026),这表明α-亚麻酸对乳腺癌风险具有保护作用。膳食α-亚麻酸对乳腺癌风险的影响值得进一步研究。