Lamnaouer D
Institut Agronomique et Vétérinaire Hassan II, Département de Pharmacie Toxicologie et Biochimie, Rabat-Instituts, Maroc.
Therapie. 1999 Nov-Dec;54(6):747-51.
Ferula communis is an ombelliferous plant of the Mediterranean regions. It is represented in Morocco by two varieties: brevifolia and genuina. The later is very rich in a soap or resinous gum. This product, collected from the roots, is largely used in traditional medicine. It is know as fessoukh in Morocco and other Arab countries. This plant is also well known for its toxicity and its anticoagulant activity. In the present review, are discussed: (1) the ethnobotany of the plant, especially medicinal uses of fessoukh in traditional medicine as well as alimentary use of young stems as legumes; (2) clinical and biochemical data of intoxication by this plant, which are dominated by haemorrhage as a consequence of blood coagulation disturbance; (3) 4-hydroxycoumarins isolated from Ferula communis L. and their anticoagulant activity; (4) the role of vitamin K1 in the treatment of poisoning by this plant.
阿魏是一种生长在地中海地区的伞形科植物。在摩洛哥，它有两个变种：短叶阿魏和原种阿魏。后者富含一种皂类或树脂状树胶。这种从根部采集的产品在传统医学中被大量使用。在摩洛哥和其他阿拉伯国家，它被称为“fessoukh”。这种植物还因其毒性和抗凝血活性而闻名。在本综述中，将讨论以下内容：（1）该植物的民族植物学，特别是fessoukh在传统医学中的药用用途以及嫩茎作为豆类的食用用途；（2）该植物中毒的临床和生化数据，其主要表现为由于凝血障碍导致的出血；（3）从阿魏中分离出的4-羟基香豆素及其抗凝血活性；（4）维生素K1在治疗该植物中毒中的作用。
