Tligui N, Ruth G R
Department of Veterinary Pathology, Institut Agronomique et Véterinaire Hassan II, Rabat, Morocco.
Am J Vet Res. 1994 Nov;55(11):1558-63.
Sheep given powdered Ferula communis variety brevifolia at dosage of 2.5 g/kg of body weight/d for 15 days developed classical clinical signs of intoxication: anorexia, somnolence, apparent weakness, and hemorrhage. Marked reduction of vitamin K-dependent coagulation factors and prolongation of prothrombin time and activated partial thromboplastin time were consistent with presence of ferulenol, a toxic coumarinic factor in the plant. Changes induced in the coagulation system developed by the second day of plant administration and were normal within 4 days after dosing was stopped. There was no evidence of primary liver damage or platelet malfunction. Of 6 intoxicated sheep, 2 died with only minimal evidence of hemorrhage.
给绵羊按2.5克/千克体重/天的剂量投喂短叶阿魏粉末，持续15天，绵羊出现了典型的中毒临床症状：厌食、嗜睡、明显虚弱和出血。维生素K依赖的凝血因子显著减少，凝血酶原时间和活化部分凝血活酶时间延长，这与植物中的有毒香豆素因子阿魏醇的存在一致。给药第二天凝血系统就出现了变化，停药后4天内恢复正常。没有原发性肝损伤或血小板功能障碍的证据。6只中毒绵羊中有2只死亡，仅有轻微出血迹象。
