Znati Mansour, Hichem Ben Jannet, Cazaux Sylvie, Bouajila Jalloul
Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse, Université Paul-Sabatier, 118 route de Narbonne, Toulouse F-31062, France.
Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (CHPNR), Equipe Chimie Médicinale et Produits Naturels, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l'Environnement, Monastir 5019, Tunisia.
Molecules. 2014 Feb 26;19(3):2733-47. doi: 10.3390/molecules19032733.
The present work describes the phytochemical study on Ferula lutea flowers. Total phenolics and flavonoids of the n-butanol and ethyl acetate extracts were quantified (phenolics [40.68-52.29 mg gallic acid equivalent/g of dry weight], flavonoids [12.38-14.72 mg quercitin/g dry weight]). Two diastereoisomers were isolated and identified using spectroscopic techniques (1D, 2D NMR and GC-MS). The extracts and diastereoisomers were tested for antioxidant, antiacetylcholinesterase, antimicrobial, antidiabectic, cytotoxic (leukemia cell line) activities and allelopathic potentialities. The strongest antioxidant activity was obtained for the ethyl acetate extract (IC₅₀ = 12.8 ± 1.29 µg/mL). The two extracts exhibited high antidiabetic activity (54.1 and 52.1% at 40 µg/mL).
本研究描述了对阿魏花的植物化学研究。对正丁醇提取物和乙酸乙酯提取物中的总酚类和黄酮类进行了定量分析（酚类[40.68 - 52.29毫克没食子酸当量/克干重]，黄酮类[12.38 - 14.72毫克槲皮素/克干重]）。使用光谱技术（一维、二维核磁共振和气相色谱 - 质谱联用）分离并鉴定了两种非对映异构体。对提取物和非对映异构体进行了抗氧化、抗乙酰胆碱酯酶、抗菌、抗糖尿病、细胞毒性（白血病细胞系）活性以及化感潜力测试。乙酸乙酯提取物的抗氧化活性最强（IC₅₀ = 12.8 ± 1.29微克/毫升）。两种提取物在40微克/毫升时均表现出较高的抗糖尿病活性（分别为54.1%和52.1%）。
