瘦型和遗传性肥胖ob/ob小鼠的肝脏Δ6-去饱和酶活性
Hepatic delta 6-desaturase activity in lean and genetically obese ob/ob mice.
作者信息
Hughes S, York D A
出版信息
Biochem J. 1985 Jan 15;225(2):307-13. doi: 10.1042/bj2250307.
Abstract
Hepatic delta 6-desaturase activity is primarily located in the mitochondrial fraction in mice. Both delta 6- and delta 5-desaturase activities are increased in the liver of young (6-week-old) obese mice. The increase in hepatic delta 6-desaturase activity in obese mice does not occur until weaning. Neither restriction of food intake nor hyperinsulinaemia normalize hepatic delta 6-desaturase activity of obese mice. Both cold acclimation and tri-iodothyronine (30 micrograms/day per kg) decreased hepatic delta 6-desaturase activity of obese mice to levels observed in lean mice, whereas the increase in activity in obese mice was still maintained after the induction of hypothyroidism.
摘要
在小鼠中，肝脏Δ6-去饱和酶活性主要位于线粒体部分。在年轻（6周龄）肥胖小鼠的肝脏中，Δ6-和Δ5-去饱和酶活性均升高。肥胖小鼠肝脏中Δ6-去饱和酶活性的增加直到断奶时才出现。限制食物摄入量或高胰岛素血症均不能使肥胖小鼠的肝脏Δ6-去饱和酶活性恢复正常。冷适应和三碘甲状腺原氨酸（每千克每天30微克）均可使肥胖小鼠肝脏Δ6-去饱和酶活性降低至瘦小鼠中的水平，而在诱发甲状腺功能减退后，肥胖小鼠中该酶活性的增加仍得以维持。
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2
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3
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