Prescott G J, Lee R J, Cohen G R, Elton R A, Lee A J, Fowkes F G, Agius R M
Department of Community Health Sciences, University of Edinburgh, UK.
Occup Environ Med. 2000 Jan;57(1):53-7. doi: 10.1136/oem.57.1.53.
To determine whether previous symptoms or recognized risk factors of cardiovascular ill health, are associated with an increased likelihood of adverse health effects related to particulate air pollution.
Cardiovascular event rates were studied relative to urban concentrations of particulate air pollution and baseline risk factors. The Edinburgh artery study consisted of a cohort of 1592 subjects aged 55-74 and was followed up to the end of March 1998 for a median of 10 years resulting in about 5 million person-days of observation. Baseline measurements included plasma fibrinogen and blood and plasma viscosity. A nested case-control approach was used to investigate a possible interaction between effects of these selected baseline risk factors and particulate air pollution, on subsequent event rates.
During the follow up period there were 343 fatal and non-fatal myocardial infarctions or strokes. Trends in adverse cardiovascular outcomes related to pollution were identified among subjects belonging to the highest baseline quintile of plasma fibrinogen. Evidence for interactions between concentrations of particulate pollution and fibrinogen was not established at conventional levels of significance.
People with high concentrations of plasma fibrinogen might be more susceptible to adverse cardiovascular effects of particulate air pollution, but limitations of power mean that evidence relating to such an interaction is not conclusive. A range of cardiopulmonary risk factors warrant investigation in relation to possible susceptibility to air pollution.
确定既往心血管健康不良症状或公认的风险因素是否与颗粒物空气污染相关的不良健康影响可能性增加有关。
研究心血管事件发生率与城市颗粒物空气污染浓度及基线风险因素的关系。爱丁堡动脉研究纳入了1592名年龄在55 - 74岁的受试者队列，随访至1998年3月底，中位随访时间为10年，累计观察约500万人日。基线测量包括血浆纤维蛋白原、血液和血浆粘度。采用巢式病例对照方法研究这些选定的基线风险因素与颗粒物空气污染的影响对后续事件发生率的可能相互作用。
在随访期间，发生了343例致命和非致命性心肌梗死或中风。在血浆纤维蛋白原基线水平最高的五分位数受试者中，发现了与污染相关的不良心血管结局趋势。在传统显著性水平上未证实颗粒物污染浓度与纤维蛋白原之间存在相互作用的证据。
血浆纤维蛋白原浓度高的人可能更容易受到颗粒物空气污染对心血管的不良影响，但由于检验效能的限制，有关这种相互作用的证据并不确凿。一系列心肺风险因素对于空气污染易感性的研究值得探讨。
