Colthurst M J, Williams R L, Hiscott P S, Grierson I
Department of Medicine, University of Liverpool, UK.
Biomaterials. 2000 Apr;21(7):649-65. doi: 10.1016/s0142-9612(99)00220-3.
The treatment of posterior segment eye disease and related conditions has improved greatly in recent years with the advent of new therapies, materials and devices. Vitreoretinal conditions, however, remain significant causes of blindness in the developed world. Biomaterials play a major role in the treatment of many of these disorders and the success rate of vitreoretinal surgery, especially in the repair of retinal detachment and related conditions, would increase with the introduction of new and improved materials. This review, which focuses on disorders that feature retinal detachment, briefly describes the anatomy of the eye and the nature and treatment of posterior segment eye disorders. The roles, required properties and suitability of the materials used in vitreoretinal surgery as scleral buckles, tamponade agents or drug delivery devices, are reviewed. Experimental approaches are discussed, along with the methods used for their evaluation, and future directions for biomaterial research in the posterior segment of the eye are considered.
近年来，随着新疗法、材料和设备的出现，后段眼病及相关病症的治疗有了很大改善。然而，在发达国家，玻璃体视网膜疾病仍是失明的主要原因。生物材料在许多此类疾病的治疗中发挥着重要作用，随着新型和改良材料的引入，玻璃体视网膜手术的成功率，尤其是视网膜脱离及相关病症的修复成功率将会提高。本综述聚焦于以视网膜脱离为特征的疾病，简要描述了眼睛的解剖结构以及后段眼病的性质和治疗方法。对用于玻璃体视网膜手术的材料，如巩膜扣带、填塞剂或药物递送装置的作用、所需特性和适用性进行了综述。讨论了实验方法及其评估方法，并探讨了眼后段生物材料研究的未来方向。
