生酮饮食在治疗进行性多发性硬化症中的治疗潜力
The Therapeutic Potential of the Ketogenic Diet in Treating Progressive Multiple Sclerosis.
作者信息
Storoni Mithu, Plant Gordon T
机构信息
Department of Neuro-Ophthalmology, The National Hospital for Neurology and Neurosurgery, Box 93, Queen Square, London WC1N 3BG, UK.
出版信息
Mult Scler Int. 2015;2015:681289. doi: 10.1155/2015/681289. Epub 2015 Dec 29.
Abstract
Until recently, multiple sclerosis has been viewed as an entirely inflammatory disease without acknowledgment of the significant neurodegenerative component responsible for disease progression and disability. This perspective is being challenged by observations of a dissociation between inflammation and neurodegeneration where the neurodegenerative component may play a more significant role in disease progression. In this review, we explore the relationship between mitochondrial dysfunction and neurodegeneration in multiple sclerosis. We review evidence that the ketogenic diet can improve mitochondrial function and discuss the potential of the ketogenic diet in treating progressive multiple sclerosis for which no treatment currently exists.
摘要
直到最近，多发性硬化症一直被视为一种完全的炎症性疾病，而没有认识到导致疾病进展和残疾的重要神经退行性成分。炎症与神经退行性变之间的分离现象的观察结果对这一观点提出了挑战，其中神经退行性成分可能在疾病进展中发挥更重要的作用。在这篇综述中，我们探讨了线粒体功能障碍与多发性硬化症中神经退行性变之间的关系。我们回顾了生酮饮食可以改善线粒体功能的证据，并讨论了生酮饮食在治疗目前尚无治疗方法的进展性多发性硬化症方面的潜力。
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