脂质体两性霉素B（安必素）成功非手术治疗热带念珠菌性心内膜炎。

Successful non-surgical treatment of Candida tropicalis endocarditis with liposomal amphotericin-B (AmBisome).

作者信息

Melamed R, Leibovitz E, Abramson O, Levitas A, Zucker N, Gorodisher R

机构信息

Pediatric Infectious Unit, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

出版信息

Scand J Infect Dis. 2000;32(1):86-9. doi: 10.1080/00365540050164281.

DOI:10.1080/00365540050164281

PMID:10716084

Abstract

Fungal endocarditis in children is most commonly a complication of palliative or curative surgery for congenital heart disease, rheumatic valvulitis and prolonged indwelling central venous and umbilical catheters. We describe here the case of a 3-y-old patient with chronic diarrhoea and prolonged total parenteral alimentation who developed severe C. tropicalis endocarditis and was treated successfully using a liposomal preparation of amphotericin-B (AmBisome) without surgical intervention.

摘要

儿童真菌性心内膜炎最常见于先天性心脏病姑息性或根治性手术、风湿性瓣膜炎以及长期留置中心静脉导管和脐静脉导管后的并发症。我们在此描述一名3岁慢性腹泻且长期接受全胃肠外营养的患儿，其发生了严重的热带念珠菌性心内膜炎，在未进行手术干预的情况下，使用两性霉素B脂质体制剂（安必素）成功治愈。