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巴西念珠菌病管理指南——三个医学协会的联合会议报告:巴西传染病学会、圣保罗传染病学会和巴西热带医学学会。

Brazilian guidelines for the management of candidiasis - a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical.

机构信息

Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.

出版信息

Braz J Infect Dis. 2013 May-Jun;17(3):283-312. doi: 10.1016/j.bjid.2013.02.001. Epub 2013 May 18.

DOI:10.1016/j.bjid.2013.02.001
PMID:23693017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9427385/
Abstract

Candida infections account for 80% of all fungal infections in the hospital environment, including bloodstream, urinary tract and surgical site infections. Bloodstream infections are now a major challenge for tertiary hospitals worldwide due to their high prevalence and mortality rates. The incidence of candidemia in tertiary public hospitals in Brazil is approximately 2.5 cases per 1000 hospital admissions. Due to the importance of this infection, the authors provide a review of the diversity of the genus Candida and its clinical relevance, the therapeutic options and discuss the treatment of major infections caused by Candida. Each topography is discussed with regard to epidemiological, clinical and laboratory diagnostic and therapeutic recommendations based on levels of evidence.

摘要

念珠菌感染占医院环境中所有真菌感染的 80%,包括血流感染、尿路感染和手术部位感染。由于其高患病率和死亡率,血流感染现在是全球三级医院面临的主要挑战。巴西三级公立医院的念珠菌血症发病率约为每 1000 例住院患者 2.5 例。鉴于这种感染的重要性,作者对念珠菌属的多样性及其临床相关性、治疗选择进行了综述,并讨论了念珠菌引起的主要感染的治疗。根据证据水平,对每个部位的流行病学、临床和实验室诊断以及治疗建议进行了讨论。

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本文引用的文献

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Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials.治疗策略对念珠菌血症和其他形式侵袭性念珠菌病患者结局的影响:随机试验的患者水平定量评价。
Clin Infect Dis. 2012 Apr;54(8):1110-22. doi: 10.1093/cid/cis021. Epub 2012 Mar 12.
2
Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance.棘白菌素耐药相关的白念珠菌 FKS1 热点突变的适应性和毒力代价。
J Infect Dis. 2011 Aug 15;204(4):626-35. doi: 10.1093/infdis/jir351.
3
Ocular manifestations of candidemia.眼内念珠菌病的表现。
Clin Infect Dis. 2011 Aug 1;53(3):262-8. doi: 10.1093/cid/cir355.
4
Epidemiology and treatment approaches in management of invasive fungal infections.侵袭性真菌感染的流行病学和治疗方法。
Clin Epidemiol. 2011;3:175-91. doi: 10.2147/CLEP.S12502. Epub 2011 May 19.
5
Interlaboratory evaluation of VITEK2 system and Sensititre YeastOne® for antifungal susceptibility testing of yeasts isolated from blood cultures against four antifungal agents.VITEK2系统和Sensititre YeastOne®对从血培养中分离出的酵母针对四种抗真菌药物进行抗真菌药敏试验的实验室间评估。
New Microbiol. 2011 Apr;34(2):195-201. Epub 2011 Apr 30.
6
Adaptation, adhesion and invasion during interaction of Candida albicans with the host--focus on the function of cell wall proteins.白色念珠菌与宿主相互作用过程中的适应、黏附和侵袭——聚焦细胞壁蛋白的功能。
Int J Med Microbiol. 2011 Jun;301(5):384-9. doi: 10.1016/j.ijmm.2011.04.004. Epub 2011 May 14.
7
[Candidemia: impact of epidemiological studies on the treatment and prognosis of a serious infection].[念珠菌血症:流行病学研究对一种严重感染的治疗和预后的影响]
Enferm Infecc Microbiol Clin. 2011 May;29(5):325-7. doi: 10.1016/j.eimc.2011.03.002.
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Candida bloodstream infections: comparison of species distribution and resistance to echinocandin and azole antifungal agents in Intensive Care Unit (ICU) and non-ICU settings in the SENTRY Antimicrobial Surveillance Program (2008-2009).念珠菌血流感染:重症监护病房(ICU)和非 ICU 环境下 SENTRY 抗菌监测计划(2008-2009 年)中,菌种分布和棘白菌素类及唑类抗真菌药物耐药性的比较。
Int J Antimicrob Agents. 2011 Jul;38(1):65-9. doi: 10.1016/j.ijantimicag.2011.02.016. Epub 2011 Apr 22.
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Candida urinary tract infections--treatment.念珠菌性尿路感染——治疗。
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