Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Braz J Infect Dis. 2013 May-Jun;17(3):283-312. doi: 10.1016/j.bjid.2013.02.001. Epub 2013 May 18.
Candida infections account for 80% of all fungal infections in the hospital environment, including bloodstream, urinary tract and surgical site infections. Bloodstream infections are now a major challenge for tertiary hospitals worldwide due to their high prevalence and mortality rates. The incidence of candidemia in tertiary public hospitals in Brazil is approximately 2.5 cases per 1000 hospital admissions. Due to the importance of this infection, the authors provide a review of the diversity of the genus Candida and its clinical relevance, the therapeutic options and discuss the treatment of major infections caused by Candida. Each topography is discussed with regard to epidemiological, clinical and laboratory diagnostic and therapeutic recommendations based on levels of evidence.
念珠菌感染占医院环境中所有真菌感染的 80%,包括血流感染、尿路感染和手术部位感染。由于其高患病率和死亡率,血流感染现在是全球三级医院面临的主要挑战。巴西三级公立医院的念珠菌血症发病率约为每 1000 例住院患者 2.5 例。鉴于这种感染的重要性,作者对念珠菌属的多样性及其临床相关性、治疗选择进行了综述,并讨论了念珠菌引起的主要感染的治疗。根据证据水平,对每个部位的流行病学、临床和实验室诊断以及治疗建议进行了讨论。