春化作用的分子基础：开花位点C（FLC）的核心作用。
The molecular basis of vernalization: the central role of FLOWERING LOCUS C (FLC).
作者信息
Sheldon C C, Rouse D T, Finnegan E J, Peacock W J, Dennis E S
机构信息
Commonwealth Scientific and Industrial Research Organization, Division of Plant Industry, G.P.O. Box 1600, Canberra, ACT 2600, Australia.
出版信息
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3753-8. doi: 10.1073/pnas.97.7.3753.
In Arabidopsis, the MADS-box protein encoded by FLOWERING LOCUS C (FLC) is a repressor of flowering. Vernalization, which promotes flowering in the late-flowering ecotypes and many late-flowering mutants, decreases the level of FLC transcript and protein in the plant. This vernalization-induced reduction in FLC transcript levels is mitotically stable and occurs in all tissues. FLC activity is restored in each generation, as is the requirement of a low-temperature exposure for the promotion of flowering. The level of FLC determines the extent of the vernalization response in the promotion of flowering, and there is a quantitative relationship between the duration of cold treatment and the extent of down-regulation of FLC activity. We conclude that FLC is the central regulator of the induction of flowering by vernalization. Other vernalization-responsive late-flowering mutants, which are disrupted in genes that encode regulators of FLC, are late-flowering as a consequence of their elevated levels of FLC.
在拟南芥中，由开花位点C（FLC）编码的MADS-box蛋白是开花的抑制因子。春化作用可促进晚花生态型和许多晚花突变体开花，它会降低植物中FLC转录本和蛋白质的水平。这种春化作用诱导的FLC转录本水平降低在有丝分裂过程中是稳定的，并且发生在所有组织中。FLC活性在每一代中都会恢复，促进开花所需的低温暴露条件也是如此。FLC的水平决定了春化作用促进开花的响应程度，并且冷处理持续时间与FLC活性下调程度之间存在定量关系。我们得出结论，FLC是春化作用诱导开花的核心调节因子。其他对春化作用有响应的晚花突变体，其编码FLC调节因子的基因发生了突变，由于FLC水平升高而表现为晚花。
Zotero 插件