Prates V, Cobos M, Bouzas B, Napal J, Bordone J, Milone J
Instituto de Trasplante de Médula Osea, Fundación Mainetti, La Plata, Argentina.
Leuk Lymphoma. 2000 Mar;37(1-2):225-7. doi: 10.3109/10428190009057650.
Here we describe two Caucasian brothers who developed adult T-cell leukemia/lymphoma (ATLL), within a short period of time. These two patients have never left Argentina. Their parents are dead and according to the family history it is possible that the mother may have been affected by spastic paraparesis. The daughters reported that their mother had suffered from increasing difficulty in walking for many years which finally made it impossible for to her walk. There are no other data to support the presumptive diagnosis. One of the patients presented with acute disease while the other had a lymphoma type disorder. Both were positive for HTLV 1. The first patient died with disease progression ten months after diagnosis and the second is in partial remission 13 months after diagnosis. Immunophenotyping showed CD4+, CD5+, CD3+, CD2+, CD8 (-). Two asymptomatic brothers with positive HTLV 1 serology were detected. This is the first family case that has been reported in Argentina.
在此，我们描述了两名高加索兄弟，他们在短时间内患上了成人T细胞白血病/淋巴瘤（ATLL）。这两名患者从未离开过阿根廷。他们的父母均已去世，根据家族病史，母亲可能曾患有痉挛性截瘫。女儿们报告说，她们的母亲多年来行走困难日益加重，最终无法行走。没有其他数据支持这一推测性诊断。其中一名患者表现为急性疾病，另一名患有淋巴瘤型疾病。两人HTLV 1均呈阳性。第一名患者在诊断后十个月因疾病进展死亡，第二名患者在诊断后13个月处于部分缓解状态。免疫表型分析显示CD4 +、CD5 +、CD3 +、CD2 +、CD8（-）。检测到两名HTLV 1血清学阳性的无症状兄弟。这是阿根廷报告的首例家族病例。
