棘白菌素类、唑类和多烯类抗真菌药物对白色念珠菌和新型隐球菌的抗真菌后效应
Postantifungal effects of echinocandin, azole, and polyene antifungal agents against Candida albicans and Cryptococcus neoformans.
作者信息
Ernst E J, Klepser M E, Pfaller M A
机构信息
College of Pharmacy, The University of Iowa, Department of Pathology, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
出版信息
Antimicrob Agents Chemother. 2000 Apr;44(4):1108-11. doi: 10.1128/AAC.44.4.1108-1111.2000.
Abstract
The postantifungal effect (PAFE) of fluconazole, MK-0991, LY303366, and amphotericin B was determined against isolates of Candida albicans and Cryptococcus neoformans. Concentrations ranging from 0. 125 to 4 times the MIC were tested following exposure to the antifungal for 0.25 to 1 h. Combinations of azole and echinocandin antifungals (MK-0991 and LY303366) were tested against C. neoformans. Fluconazole displayed no measurable PAFE against Candida albicans or Cryptococcus neoformans, either alone or in combination with either echinocandin antifungal. MK-0991, LY303366, and amphotericin B displayed a prolonged PAFE of greater than 12 h against Candida spp. when tested at concentrations above the MIC for the organism and 0 to 2 h when tested at concentrations below the MIC for the organism.
摘要
测定了氟康唑、MK-0991、LY303366和两性霉素B对白色念珠菌和新型隐球菌分离株的抗真菌后效应（PAFE）。在接触抗真菌药物0.25至1小时后，测试了0.125至4倍MIC的浓度。测试了唑类和棘白菌素类抗真菌药物（MK-0991和LY303366）对新型隐球菌的联合作用。氟康唑单独或与任何一种棘白菌素类抗真菌药物联合使用时，对白色念珠菌或新型隐球菌均未显示出可测量的PAFE。当以高于该生物体MIC的浓度进行测试时，MK-0991、LY303366和两性霉素B对念珠菌属显示出大于12小时的延长PAFE，而当以低于该生物体MIC的浓度进行测试时，PAFE为0至2小时。
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