Ernst E J, Klepser M E, Pfaller M A
College of Pharmacy, The University of Iowa, Department of Pathology, The University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.
Antimicrob Agents Chemother. 2000 Apr;44(4):1108-11. doi: 10.1128/AAC.44.4.1108-1111.2000.
The postantifungal effect (PAFE) of fluconazole, MK-0991, LY303366, and amphotericin B was determined against isolates of Candida albicans and Cryptococcus neoformans. Concentrations ranging from 0. 125 to 4 times the MIC were tested following exposure to the antifungal for 0.25 to 1 h. Combinations of azole and echinocandin antifungals (MK-0991 and LY303366) were tested against C. neoformans. Fluconazole displayed no measurable PAFE against Candida albicans or Cryptococcus neoformans, either alone or in combination with either echinocandin antifungal. MK-0991, LY303366, and amphotericin B displayed a prolonged PAFE of greater than 12 h against Candida spp. when tested at concentrations above the MIC for the organism and 0 to 2 h when tested at concentrations below the MIC for the organism.
测定了氟康唑、MK-0991、LY303366和两性霉素B对白色念珠菌和新型隐球菌分离株的抗真菌后效应（PAFE）。在接触抗真菌药物0.25至1小时后，测试了0.125至4倍MIC的浓度。测试了唑类和棘白菌素类抗真菌药物（MK-0991和LY303366）对新型隐球菌的联合作用。氟康唑单独或与任何一种棘白菌素类抗真菌药物联合使用时，对白色念珠菌或新型隐球菌均未显示出可测量的PAFE。当以高于该生物体MIC的浓度进行测试时，MK-0991、LY303366和两性霉素B对念珠菌属显示出大于12小时的延长PAFE，而当以低于该生物体MIC的浓度进行测试时，PAFE为0至2小时。
