金黄色葡萄球菌肠毒素B对雪貂催吐、发热及行为影响的诱导作用
Induction of emetic, pyrexic, and behavioral effects of Staphylococcus aureus enterotoxin B in the ferret.
作者信息
Wright A, Andrews P L, Titball R W
机构信息
Defence Evaluation and Research Agency, CBD Porton Down, Salisbury, Wiltshire SP4 OJQ, United Kingdom.
出版信息
Infect Immun. 2000 Apr;68(4):2386-9. doi: 10.1128/IAI.68.4.2386-2389.2000.
Abstract
Ferrets which had been orally dosed with 5 mg of Staphylococcal enterotoxin B (SEB) responded with an increase in subcutaneous temperature. At 75 min, the subcutaneous temperature was significantly higher (+ 0.9 degrees C +/- 0.38 degrees C, P < 0.007) than in control animals. Animals dosed with 1 or 2 mg of SEB responded with a small, but not significant, increase in subcutaneous temperature. All of the animals dosed with 5 mg of SEB retched and vomited. The mean latency for the onset of retching was 105 +/- 36 min, and the mean latency for the onset of vomiting was 106 +/- 34 min. The mean number of retches was 17.8 +/- 19.6, and the mean number of vomits was 2.0 +/- 1.5. These findings indicate that ferrets can be used as alternatives to primates for the study of the biological activities of SEB.
摘要
经口服给予5毫克葡萄球菌肠毒素B（SEB）的雪貂，其皮下温度会升高。在75分钟时，皮下温度显著高于对照动物（升高0.9摄氏度±0.38摄氏度，P<0.007）。给予1或2毫克SEB的动物，其皮下温度有小幅升高，但不显著。所有给予5毫克SEB的动物均出现干呕和呕吐。干呕发作的平均潜伏期为105±36分钟，呕吐发作的平均潜伏期为106±34分钟。干呕的平均次数为17.8±19.6次，呕吐的平均次数为2.0±1.5次。这些发现表明，雪貂可作为灵长类动物的替代物用于SEB生物活性的研究。
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