Henriksson G, Manthorpe R, Bredberg A
Department of Medical Microbiology, University Hospital, Malmö and. Sjögren's Syndrome Research Centre, Department of Rheumatology, University Hospital, Malmö, Sweden.
Rheumatology (Oxford). 2000 Feb;39(2):142-7. doi: 10.1093/rheumatology/39.2.142.
The purpose of this study was to examine whether antibodies against CD4 are present in patients with primary Sjögren's syndrome, and to explore the possible correlation between these antibodies and the CD4+ T lymphocyte depletion that is seen in some Sjögren patients.
Sera from 214 patients with primary Sjögren's syndrome, 154 healthy blood donors, 38 age- and sex-matched controls without autoimmune disease, and 77 HIV-1-seropositive individuals were analysed by an enzyme-linked immunosorbent assay (ELISA) using recombinant soluble CD4 as the antigen.
Anti-CD4 antibodies were observed more frequently in patients with Sjögren's syndrome (12.6%) as compared with the control groups (0.6%) (P < 0.001), and at a level similar to that seen among the HIV-1 patients (13.0%). However, no correlation was found between the presence of anti-CD4 antibodies and CD4+ T lymphocytopenia in the Sjögren patients.
This is the first study that shows anti-CD4 antibodies in patients with primary Sjögren's syndrome. The significance of these antibodies in the immunopathogenesis of Sjögren's syndrome remains to be determined.
本研究旨在检测原发性干燥综合征患者体内是否存在抗CD4抗体，并探讨这些抗体与部分干燥综合征患者出现的CD4+T淋巴细胞耗竭之间可能存在的相关性。
采用重组可溶性CD4作为抗原，通过酶联免疫吸附测定（ELISA）法对214例原发性干燥综合征患者、154例健康献血者、38例年龄和性别匹配的无自身免疫性疾病对照者以及77例HIV-1血清阳性个体的血清进行分析。
与对照组（0.6%）相比，干燥综合征患者中抗CD4抗体的检出频率更高（12.6%）（P<0.001），且与HIV-1患者中的检出水平（13.0%）相似。然而，在干燥综合征患者中，未发现抗CD4抗体的存在与CD4+T淋巴细胞减少之间存在相关性。
这是首次在原发性干燥综合征患者中发现抗CD4抗体的研究。这些抗体在干燥综合征免疫发病机制中的意义仍有待确定。
