Rubin G M, Yandell M D, Wortman J R, Gabor Miklos G L, Nelson C R, Hariharan I K, Fortini M E, Li P W, Apweiler R, Fleischmann W, Cherry J M, Henikoff S, Skupski M P, Misra S, Ashburner M, Birney E, Boguski M S, Brody T, Brokstein P, Celniker S E, Chervitz S A, Coates D, Cravchik A, Gabrielian A, Galle R F, Gelbart W M, George R A, Goldstein L S, Gong F, Guan P, Harris N L, Hay B A, Hoskins R A, Li J, Li Z, Hynes R O, Jones S J, Kuehl P M, Lemaitre B, Littleton J T, Morrison D K, Mungall C, O'Farrell P H, Pickeral O K, Shue C, Vosshall L B, Zhang J, Zhao Q, Zheng X H, Lewis S
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, Berkeley Drosophila Genome Project, University of California, Berkeley, CA 94720, USA.
Science. 2000 Mar 24;287(5461):2204-15. doi: 10.1126/science.287.5461.2204.
A comparative analysis of the genomes of Drosophila melanogaster, Caenorhabditis elegans, and Saccharomyces cerevisiae-and the proteins they are predicted to encode-was undertaken in the context of cellular, developmental, and evolutionary processes. The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast. The fly has orthologs to 177 of the 289 human disease genes examined and provides the foundation for rapid analysis of some of the basic processes involved in human disease.
在细胞、发育和进化过程的背景下,对黑腹果蝇、秀丽隐杆线虫和酿酒酵母的基因组以及预测它们编码的蛋白质进行了比较分析。果蝇和线虫的非冗余蛋白质组在大小上相似,仅为酵母的两倍,但每个基因组中不同的基因家族都有所扩展,而且果蝇和线虫的多结构域蛋白质和信号通路比酵母的要复杂得多。在所研究的289个人类疾病基因中,果蝇有177个直系同源基因,为快速分析人类疾病所涉及的一些基本过程奠定了基础。