Shipley W U, Tepper J E, Prout G R, Verhey L J, Mendiondo O A, Goitein M, Koehler A M, Suit H D
JAMA. 1979 May 4;241(18):1912-5.
A 160-MeV proton beam has been modified to irradiate patients with localized tumors by using convention treatment schedules. This proton beam has the physical advantage of megavoltage x-rays of reducing the radiation dose to normal tissues adjacent to the tumor volume. A perineal proton technique used as boost therapy (2,000 to 2,500 rads) was evaluated in the definitive irradiation of 17 patients with localized prostatic carcinoma. This technique allows repeated daily treatment of the carefully defined target volume with a precision of +/- 2 mm. Total dose to the prostatic tumor, but not to the posterior rectum, has been increased by 500 to 700 rads. After 12 to 27 months of observation, no noteworthy rectal reaction has developed in a patient, easily managed urethral strictures have developed in two patients, and all but one are locally controlled.
通过使用传统治疗方案，已对160兆电子伏特的质子束进行了调整，以用于对患有局部肿瘤的患者进行照射。这种质子束具有兆伏级X射线的物理优势，即能减少对肿瘤体积附近正常组织的辐射剂量。对17例局限性前列腺癌患者进行根治性放疗时，评估了用作强化治疗（2000至2500拉德）的会阴质子技术。该技术允许每天对精心界定的靶区进行重复治疗，精度为±2毫米。前列腺肿瘤的总剂量增加了500至700拉德，但直肠后部的剂量未增加。经过12至27个月的观察，没有患者出现值得注意的直肠反应，两名患者出现了易于处理的尿道狭窄，除一名患者外，所有患者的肿瘤均得到局部控制。
