Kaiser K S
Emerging Illness Division, Naval Health Research Center, San Diego, CA 92186-5122, USA.
Mil Med. 2000 Mar;165(3):165-8.
Many Persian Gulf War veterans took pyridostigmine bromide (PB) during the Persian Gulf War. Previous research suggests that PB intake and insecticide exposure may reduce muscular strength. During 1994 and 1995, we examined the relationships between self-reported PB intake, self-reported exposures, and handgrip strength among 527 Gulf War veterans (GWVs) and 969 nondeployed veterans of that era (NDVs). We found that 25.4% and 6.7% of the GWVs and NDVs, respectively, reported generalized musucle weakness (for 1 month or longer) since the Gulf War (July 1990). Many veterans also reported exposure to insecticide during the war. Dominant handgrip strength was measured three times with a hand-held dynamometer in subjects standing with the elbow bent at a right angle. Multiple linear regression revealed that handgrip strength was negatively associated with age (p = 0.001) and female gender (p < 0.001). Handgrip strength was also found to be positively associated with height (p < 0.001), but it was not associated with PB intake (p = 0.558). Exposure to insecticides had no major effect on handgrip strength. These data suggest no association between PB intake and postwar handgrip strength.
许多海湾战争退伍军人在海湾战争期间服用了溴吡斯的明（PB）。先前的研究表明，摄入PB和接触杀虫剂可能会降低肌肉力量。在1994年至1995年期间，我们研究了527名海湾战争退伍军人（GWVs）和969名那个时代未参战的退伍军人（NDVs）中自我报告的PB摄入量、自我报告的接触情况与握力之间的关系。我们发现，自海湾战争（1990年7月）以来，分别有25.4%的GWVs和6.7%的NDVs报告有全身肌肉无力（持续1个月或更长时间）。许多退伍军人还报告在战争期间接触过杀虫剂。让受试者站立，肘部弯曲成直角，用手持式测力计对优势手握力进行了三次测量。多元线性回归显示，握力与年龄呈负相关（p = 0.001），与女性性别呈负相关（p < 0.001）。还发现握力与身高呈正相关（p < 0.001），但与PB摄入量无关（p = 0.558）。接触杀虫剂对握力没有重大影响。这些数据表明PB摄入量与战后握力之间没有关联。
