Spencer P S, McCauley L A, Lapidus J A, Lasarev M, Joos S K, Storzbach D
Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, CROET Mailcode L606, Portland, OR 97201, USA.
J Occup Environ Med. 2001 Dec;43(12):1041-56. doi: 10.1097/00043764-200112000-00006.
Many factors have been considered as possible causes of the unexplained illness reported by veterans of the Gulf War (GW). In this study, we report an analysis of risk factors and unexplained illness in a population-based sample of GW veterans who underwent clinical evaluation. Multiple risk factors were compared in 241 veterans who met criteria for unexplained illness and 113 healthy controls. Results suggest that GW unexplained illness is most highly associated with combat conditions, heat stress, and having sought medical attention during the GW. When controlling for multiple simultaneous exposures during the GW, interactions around pyridostigmine bromide, insecticides and repellents, and stress were not significant. These results indicate that most unexplained illness in GW veterans cannot be explained by neurotoxic effects of exposures to chemicals that inhibit cholinesterase activity.
许多因素被认为是海湾战争（GW）退伍军人报告的不明原因疾病的可能病因。在本研究中，我们报告了对接受临床评估的基于人群的GW退伍军人样本中的风险因素和不明原因疾病的分析。在241名符合不明原因疾病标准的退伍军人和113名健康对照中比较了多种风险因素。结果表明，GW不明原因疾病与战斗条件、热应激以及在海湾战争期间寻求医疗护理的关联最为密切。在控制海湾战争期间同时发生的多种暴露时，溴吡斯的明、杀虫剂和驱虫剂以及压力之间的相互作用并不显著。这些结果表明，海湾战争退伍军人中大多数不明原因疾病无法用接触抑制胆碱酯酶活性的化学物质的神经毒性作用来解释。
