Strandhagen E, Hansson P O, Bosaeus I, Isaksson B, Eriksson H
The Section of Preventive Medicine, at the Department of Medicine, Sahlgrenska University Hospital/östra, Göteborg, Sweden.
Eur J Clin Nutr. 2000 Apr;54(4):337-41. doi: 10.1038/sj.ejcn.1600959.
A number of long-term population-based studies have tried to study fruit and vegetable consumption in relation to cardiovascular disease, cancer and total mortality. Few of these studies are based on randomly selected population samples. The aim of the study was to investigate the long-term effect of fruit and vegetable consumption on mortality, cardiovascular disease, cardiovascular death, cancer morbidity and cancer death among middle-aged and elderly men.
Prospective cohort study.
General community. The Study of Men Born in 1913.
792 men at age 54 who participated in a screening examination in 1967.
A food frequency questionnaire was used to obtain information of the dietary habits in 730 of the men (92%). All men were followed up with repeated examinations until the age of 80.
Cardiovascular as well as total mortality was significantly lower among men with high fruit consumption in univariate analysis. There was no correlation between fruit or vegetable consumption in relation to cancer incidence, cancer death and cardiovascular disease. In multivariate survival analysis where smoking, cholesterol and hypertension were taken into account, there was a significantly lower mortality among men with a high fruit consumption during 16 y follow up until the age of 70 (P=0.042), but this finding was no longer statistically significant during 26 y follow-up at the age of 80 (P=0.051).
Daily fruit consumption seems to have positive effect on long-term survival independently of other traditional cardiovascular risk factors like smoking, hypertension and cholesterol.
This study was supported by grants from the Swedish Medical Research Council (K98-274-06276-17) King Gustav V and Queen Victoria's Foundation, and the Göteborg University.
多项基于人群的长期研究试图探究水果和蔬菜摄入量与心血管疾病、癌症及全因死亡率之间的关系。但这些研究中很少有基于随机抽取的人群样本。本研究旨在调查水果和蔬菜摄入量对中老年男性死亡率、心血管疾病、心血管疾病死亡、癌症发病率及癌症死亡率的长期影响。
前瞻性队列研究。
普通社区。1913年出生男性研究。
792名54岁男性，他们于1967年参加了一次筛查检查。
使用食物频率问卷获取了730名男性（92%）的饮食习惯信息。对所有男性进行重复检查直至80岁。
单因素分析显示，水果摄入量高的男性心血管疾病及全因死亡率显著较低。水果或蔬菜摄入量与癌症发病率、癌症死亡率及心血管疾病之间无相关性。在多因素生存分析中，纳入吸烟、胆固醇和高血压因素后，在随访至70岁的16年期间，水果摄入量高的男性死亡率显著较低（P=0.042），但在随访至80岁的26年期间，这一结果不再具有统计学意义（P=0.051）。
每日食用水果似乎对长期生存具有积极影响，且独立于吸烟、高血压和胆固醇等其他传统心血管危险因素。
本研究得到了瑞典医学研究理事会（K98 - 274 - 06276 - 17）、古斯塔夫五世国王和维多利亚女王基金会以及哥德堡大学的资助。
