Noguera Aguilar J F, Zurita Romero M, Tortajada Collado C, Amengual Antich I, Soro Gosálvez J A, Rial Planas R
General Surgery and Digestive Diseases Service, Son Dureta University Hospital, Baleares, Spain.
Rev Esp Enferm Dig. 2000 Jan;92(1):36-43.
The aim of the study was to find out if there are differences in the incidence of colonic tumors at the anastomosis after the inclusion of titanium or the absorbable material Lactomer in the anastomotic suture line.
Experimental study with 30 male Sprague-Dawley rats, assigned to 1 of 3 study groups: control (colonic anastomosis with interrupted suture); inclusion of titanium (8 mg) in the anastomotic suture line; and inclusion of Lactomer (8 mg) in the anastomotic line. After pharmacological carcinogenesis with 1-2 dimethylhydrazine, perianastomotic tumors were studied in the 20th postoperative week.
The inclusion of titanium in the anastomotic line led to more tumors, a larger anastomotic tumoral area and a larger percentage of tumoral area than Lactomer (p < 0.05). The inclusion of Lactomer may have a protective effect against the induction of cancer in the anastomotic area.
Titanium, a material used in mechanical instruments for digestive tract anastomoses, is not an innocuous material. Its presence in the anastomotic line can promote colonic carcinogenesis after induction. The use of mechanical staplers for colonic anastomoses should be relegated to difficult anastomoses that cannot be sewn manually.
本研究旨在探讨在吻合口缝线中加入钛或可吸收材料聚乙交酯丙交酯后，吻合口处结肠肿瘤的发生率是否存在差异。
对30只雄性斯普拉格-道利大鼠进行实验研究，将其分为3个研究组中的1组：对照组（结肠吻合采用间断缝合）；在吻合口缝线中加入钛（8毫克）；在吻合线中加入聚乙交酯丙交酯（8毫克）。在用1,2-二甲基肼进行药物致癌后，于术后第20周研究吻合口周围肿瘤。
与聚乙交酯丙交酯相比，在吻合线中加入钛会导致更多肿瘤、更大的吻合口肿瘤面积和更大的肿瘤面积百分比（p < 0.05）。加入聚乙交酯丙交酯可能对吻合口区域的癌症诱导具有保护作用。
钛是用于消化道吻合的机械器械中的一种材料，并非无害材料。其在吻合线中的存在可在诱导后促进结肠癌的发生。结肠吻合使用机械吻合器应仅限于无法手工缝合的困难吻合。
