Green M F, Kern R S, Braff D L, Mintz J
UCLA Neuropsychiatric Institute, Los Angeles, CA 90024-1759, USA.
Schizophr Bull. 2000;26(1):119-36. doi: 10.1093/oxfordjournals.schbul.a033430.
There has been a surge of interest in the functional consequences of neurocognitive deficits in schizophrenia. The published literature in this area has doubled in the last few years. In this paper, we will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome. In addition to surveying the number of replicated findings and tallying box scores of results, we will approach the review of the studies in a more thorough and empirical manner by applying a meta-analysis. Lastly, we will discuss what we see as a key limitation of this literature, specifically, the relatively narrow selection of predictor measures. This limitation has constrained identification of mediating variables that may explain the mechanisms for these relationships.
对精神分裂症神经认知缺陷的功能后果的兴趣激增。该领域已发表的文献在过去几年中增加了一倍。在本文中，我们将试图证实先前一篇综述的结论，即某些神经认知领域（二级言语记忆、即时记忆、通过卡片分类测量的执行功能和警觉性）与功能结果相关。除了调查重复研究结果的数量并统计结果的综合得分外，我们将通过应用荟萃分析以更全面和实证的方式对这些研究进行综述。最后，我们将讨论我们认为该文献的一个关键局限性，具体而言，预测指标的选择相对狭窄。这一局限性限制了对可能解释这些关系机制的中介变量的识别。
