Paolisso G, Manzella D, Rizzo M R, Barbieri M, Gambardella A, Varricchio M
University of Naples, Naples, Italy.
Eur J Clin Invest. 2000 Apr;30(4):277-84. doi: 10.1046/j.1365-2362.2000.00626.x.
Spectral analysis of heart rate variability (HRV) investigates the cardiac autonomic nervous system (ANS) activity. In particular, low frequency/high frequency (LF/HF) is considered an index of cardiac sympatho-vagal balance and is stimulated by glucose ingestion in healthy subjects. No studies have evaluated the effect of glucose ingestion on cardiac ANS in centenarians.
In 30 healthy centenarians (HC) and 25 aged subjects (AS) power spectral analysis of HRV was investigated during an oral glucose ingestion.
Glucose ingestion rose LF/HF ratio in both groups studied. Such stimulatory effects were restrained to the first 60 min of the study. Independent of age, gender, body mass index (BMI) and fasting plasma norepinephrine and FT3 concentrations, HC had basal total power (1318 +/- 546 vs. 1918 +/- 818 msec2, P < 0.01), lower low frequency (LF) (33 +/- 21 vs. 50 +/- 11 n.u., P < 0. 03), and higher high frequency (HF) (74 +/- 18 vs. 43 +/- 15 n.u., P < 0.05) than AS. Consequently, LF/HF ratio (0.43 +/- 0.07 vs. 0.91 +/- 0.05, P < 0.02) was also lower in HC than in AS. In AS, but not in HC, the baseline LF/HF ratio correlated significantly with BMI (r = 0.48, P < 0.01), waist-hip-ratio (WHR) (r = 0.45, P < 0.02), fasting plasma insulin (r = 0.49, P < 0.01) and norepinephrine (r = 0.57, P < 0.02) concentration. Glucose ingestion was associated with a significant rise in LF/HF ratio in both groups studied but per cent changes in glucose mediated stimulation of LF/HF was lower in HC than in AS. In a control study, water administration did not affect power spectral parameters of HRV.
Our study demonstrates that basal- and glucose-stimulated LF/HF, an indirect index of cardiac sympatho-vagal balance, are lower in HC than in AS.
心率变异性（HRV）的频谱分析用于研究心脏自主神经系统（ANS）的活动。特别是，低频/高频（LF/HF）被认为是心脏交感-迷走神经平衡的指标，并且在健康受试者中会受到葡萄糖摄入的刺激。尚无研究评估葡萄糖摄入对百岁老人心脏自主神经系统的影响。
对30名健康百岁老人（HC）和25名老年受试者（AS）在口服葡萄糖期间进行HRV的功率谱分析。
在两个研究组中，葡萄糖摄入均使LF/HF比值升高。这种刺激作用在研究的前60分钟内受到抑制。独立于年龄、性别、体重指数（BMI）以及空腹血浆去甲肾上腺素和FT3浓度，HC的基础总功率（1318±546对1918±818毫秒²，P<0.01）、低频（LF）较低（33±21对50±11 n.u.，P<0.03）以及高频（HF）较高（74±18对43±15 n.u.，P<0.05），均高于AS。因此，HC的LF/HF比值（0.43±0.07对0.91±0.05，P<0.02）也低于AS。在AS中，但不在HC中，基线LF/HF比值与BMI（r = 0.48，P<0.01）、腰臀比（WHR）（r = 0.45，P<0.02）、空腹血浆胰岛素（r = 0.49，P<0.01）和去甲肾上腺素（r = 0.57，P<0.02）浓度显著相关。在两个研究组中，葡萄糖摄入均与LF/HF比值的显著升高相关，但葡萄糖介导的LF/HF刺激的百分比变化在HC中低于AS。在一项对照研究中，饮水不影响HRV的功率谱参数。
我们的研究表明，作为心脏交感-迷走神经平衡的间接指标，HC的基础和葡萄糖刺激的LF/HF均低于AS。
