Kros J M, van den Berge H, Tanghe H L, Bakker S L
Department of Pathology, University Hospital Rotterdam, The Netherlands.
J Neurosurg. 2000 Apr;92(4):702-5. doi: 10.3171/jns.2000.92.4.0702.
Dissemination of gliomas outside the central nervous system without preceding neurosurgery is a rare phenomenon. Glial neoplasms presenting as bone lesions are even more rare. A case of glioblastoma multiforme (GBM) with initial presentation in the orbit following a single generalized seizure is described. Signs of intracranial hypertension resulted from subarachnoid tumor invasion. The patient was treated with whole-dose radiation therapy but survived for only 6 months following the initial presentation. An autopsy revealed a right temporal GBM with extensive subarachnoid spread and invasion in the left orbit and skull base. The literature on dissemination of primary tumors of the brain is reviewed.
胶质瘤在没有先前神经外科手术的情况下扩散至中枢神经系统外是一种罕见现象。以骨病变形式出现的胶质肿瘤更为罕见。本文描述了一例多形性胶质母细胞瘤（GBM），首发表现为单次全身性癫痫发作后眼眶病变。蛛网膜下腔肿瘤侵犯导致颅内高压症状。患者接受了全剂量放射治疗，但首发后仅存活6个月。尸检显示右颞叶GBM，伴有广泛的蛛网膜下腔扩散并侵犯左眼眶和颅底。本文对原发性脑肿瘤扩散的相关文献进行了综述。
