Yehuda S, Rabinovitz S, Carasso R L, Mostofsky D I
Department of Psychology, Bar Ilan University, Ramat Gan, Israel.
Int J Neurosci. 2000;101(1-4):73-87. doi: 10.3109/00207450008986494.
A mixture of linoleic and alpha-linolenic acids (free non-esterified unsaturated fatty acids) administered for 3 weeks prior to injection of cortisol (10 mg/kg), or prior to immersion of rats in a 10 degree C saline bath, prevented elevation of blood levels of cortisol and cholesterol and deficits in Morris water maze spatial learning that usually accompany such stressful conditions. Differences from controls on all behavioural and biochemical measures were statistically significant (P < .05). It is proposed that induction of intense stress, and the associated increase in cortisol, cholesterol and other corticosteroids may damage hippocampal structures and help account for the cognitive decline witnessed in Alzheimer's disease and other age-related conditions. The modulation of these consequences by the fatty acid mixture may provide an alternative strategy for the study of stress markers and for the development of other intervention options in humans.
在注射皮质醇（10毫克/千克）前3周，或在将大鼠浸入10摄氏度的盐水浴前，给予亚油酸和α-亚麻酸的混合物（游离非酯化不饱和脂肪酸），可防止皮质醇和胆固醇的血液水平升高，以及通常伴随此类应激状况出现的莫里斯水迷宫空间学习能力缺陷。在所有行为和生化指标上与对照组的差异具有统计学意义（P < 0.05）。有人提出，强烈应激的诱导以及皮质醇、胆固醇和其他皮质类固醇的相关增加可能会损害海马结构，并有助于解释在阿尔茨海默病和其他与年龄相关的病症中所观察到的认知衰退。脂肪酸混合物对这些后果的调节可能为研究应激标志物以及开发人类的其他干预方案提供一种替代策略。
