Yehuda S, Rabinovitz S, Mostofsky D I, Huberman M, Sredni B
Department of Psychology, Bar Ilan University, Ramat Gan, Israel.
Eur J Pharmacol. 1997 Jun 5;328(1):23-9. doi: 10.1016/s0014-2999(97)83022-1.
This study examined the possible effects of a novel mixture of fatty acids, SR-3 (a specific ratio of alpha-linolenic acids), on brain biochemistry and on learning deficits induced by injection of an agent that induces experimental allergic encephalomyelitis. Treatment with SR-3 caused a decrease in myelin and changes in the fatty acid profile of brain synaptosomes, and a learning deficit. Eighteen days of treatment with SR-3 reversed the biochemical and learning deficit significantly, but did not restore them to normal levels. We propose that, most probably, the main action of SR-3 is the modulation of the cholesterol level, which in turn causes the modulation of the fatty acid profile and enhances learning by allowing improved neuronal communication.
