Cuervo A M, Dice J F
Department of Physiology, Tufts University School of Medicine, Boston, MA, USA.
Exp Gerontol. 2000 Mar;35(2):119-31. doi: 10.1016/s0531-5565(00)00075-9.
Changes in the lysosomes of senescent tissues and organisms are common and have been used as biomarkers of aging. Lysosomes are responsible for the degradation of many macromolecules, including proteins. At least five different pathways for the delivery of substrate proteins to lysosomes are known. Three of these pathways decline with age, and the molecular explanations for these deficiencies are currently being studied. Other aspects of lysosomal proteolysis increase or do not change with age in spite of marked changes in lysosomal morphology and biochemistry. Age-related changes in certain lysosomal pathways of proteolysis remain to be studied. This area of research is important because abnormalities in lysosomal protein degradation pathways may contribute to several characteristics and pathologies associated with aging.
衰老组织和生物体的溶酶体变化很常见，并且已被用作衰老的生物标志物。溶酶体负责许多大分子的降解，包括蛋白质。已知至少有五种不同的将底物蛋白递送至溶酶体的途径。其中三种途径会随着年龄增长而衰退，目前正在研究这些缺陷的分子解释。尽管溶酶体形态和生物化学发生了显著变化，但溶酶体蛋白水解的其他方面随年龄增长而增加或没有变化。某些溶酶体蛋白水解途径中与年龄相关的变化仍有待研究。这一研究领域很重要，因为溶酶体蛋白降解途径的异常可能导致与衰老相关的几种特征和病理状况。
