Ohtsuka M, Satoh H, Inoue M, Yazawa T, Yamashita Y T, Sekizawa K, Hasegawa S
Department of Internal Medicine, University of Tsukuba, Ibaraki, Japan.
Anticancer Res. 2000 Jan-Feb;20(1B):527-30.
A 17-year-old man with high levels of serum AFP and hCG was diagnosed as having primary mediastinal GCT. Cisplatin-based chemotherapy decreased the biomarkers, but the mass showed further growth. Pathological examination of the resected mass revealed a mixture of immature and mature teratomas. Six months after the surgery, the patient died of a dissemination of neuroblastomatous cells, which were similar to those in the immature neural component of the primary tumor. A disseminated metastasis of neuroblastoma in immature mediastinal teratoma is a rare complication. Serum NSE can be a useful marker in detecting the metastasis.
一名17岁男性，血清甲胎蛋白（AFP）和人绒毛膜促性腺激素（hCG）水平升高，被诊断为原发性纵隔生殖细胞肿瘤（GCT）。基于顺铂的化疗使生物标志物水平降低，但肿块仍进一步生长。对切除肿块的病理检查显示为未成熟和成熟畸胎瘤的混合物。手术后6个月，患者死于神经母细胞瘤细胞播散，这些细胞与原发肿瘤未成熟神经成分中的细胞相似。未成熟纵隔畸胎瘤中神经母细胞瘤的播散性转移是一种罕见的并发症。血清神经元特异性烯醇化酶（NSE）在检测转移方面可能是一种有用的标志物。
