Singh G K
Division of Pediatric Cardiology, St. Louis University School of Medicine, MO, USA.
Indian J Pediatr. 1998 Mar-Apr;65(2):231-41. doi: 10.1007/BF02752299.
Kawasaki disease is the leading cause of acquired heart disease in children in many parts of the world. It is an acute systemic vasculitis of unknown etiology predominantly affecting children under 5 years of age. It is diagnosed clinically by the presence of a constellation of manifestations and exclusion of other diseases with similar findings. Children develop a spectrum of cardiovascular manifestations including coronary artery involvement in 30-35% of untreated cases with myocardial infarction and death in < or = 2% of them. Acute stage treatment is by administration of intravenous immunoglobulin and aspirin. Those with coronary artery involvement need long-term cardiac risk stratification and management because many of them will become the part of a growing pool of adults with ischemic heart disease.
川崎病是世界上许多地区儿童后天性心脏病的主要病因。它是一种病因不明的急性全身性血管炎，主要影响5岁以下儿童。临床上通过一系列表现的存在以及排除具有类似表现的其他疾病来进行诊断。儿童会出现一系列心血管表现，包括在30%-35%未经治疗的病例中出现冠状动脉受累，其中<或=2%的病例会发生心肌梗死和死亡。急性期治疗是通过静脉注射免疫球蛋白和阿司匹林。那些有冠状动脉受累的患者需要长期的心脏风险分层和管理，因为他们中的许多人将成为患有缺血性心脏病的成年人群体中的一部分。
