Nivsarkar M
B. V. Patel Pharmaceutical Education and Research Development Centre, Thaltej-Gandhinagar Highway, Gujarat, Thaltej, Ahmedabad-380, 054, India.
Biochem Biophys Res Commun. 2000 Apr 21;270(3):714-6. doi: 10.1006/bbrc.2000.2503.
Superoxide anion radical plays a significant role in inflammation, like rheumatoid arthritis. Superoxide dismutase enzyme known to dismutate superoxide anion radical does not play any significant role in this multisystem disease. This paper reports that very low levels of circulating superoxide dismutase levels are observed in patients with rheumatoid arthritis and these levels significantly improve with NSAID therapy. The possible mechanism of the action is discussed.
超氧阴离子自由基在炎症中起重要作用，如类风湿性关节炎。已知能使超氧阴离子自由基歧化的超氧化物歧化酶在这种多系统疾病中不起任何重要作用。本文报道，类风湿性关节炎患者循环中超氧化物歧化酶水平极低，且这些水平在非甾体抗炎药治疗后显著改善。文中讨论了可能的作用机制。
