Ozkan Yesim, Yardým-Akaydýn Sevgi, Sepici Aylin, Keskin Erinc, Sepici Vesile, Simsek Bolkan
Department of Biochemistry, Gazi University, Faculty of Pharmacy, Etiler-Ankara, Turkey.
Clin Rheumatol. 2007 Jan;26(1):64-8. doi: 10.1007/s10067-006-0244-z. Epub 2006 Mar 25.
The insufficiency of antioxidant defense systems and the acceleration of the oxidative reactions can be results of the pro-oxidant/antioxidant imbalance in rheumatoid arthritis (RA). The aim of our study was to investigate the changes in oxidant status by measuring two different parameters; one was the level of malondialdehyde (MDA) as an index of lipid peroxidation and the other was total oxidative status; we could then compare our results with the antioxidant status, superoxide dismutase (SOD) enyzme activities. All were assessed in 22 patients with active RA and 18 age- and gender-matched control subjects. While serum MDA levels were significantly increased in patients with RA compared to the control group (p<0.03), the total oxidative status levels were decreased in patients with RA compared to the control group (p<0.008), and serum SOD activities did not show any statistical difference between the two groups. In conclusion, the increased MDA levels in our study may be important as a marker but are not sufficient to conclude that there was an increase in oxidative stress in RA patients because supporting results were not obtained from SOD and oxidative status measurements. These results give further support to the concept of oxygen free radicals playing a role in the pathogenesis of chronic inflammatory disorders, but we also consider that there is a more complex relationship than has been assumed. We think that further studies are needed to clarify these conflicting results.
抗氧化防御系统的不足以及氧化反应的加速可能是类风湿关节炎（RA）中促氧化剂/抗氧化剂失衡的结果。我们研究的目的是通过测量两个不同参数来调查氧化状态的变化；一个是作为脂质过氧化指标的丙二醛（MDA）水平，另一个是总氧化状态；然后我们可以将我们的结果与抗氧化状态、超氧化物歧化酶（SOD）酶活性进行比较。对22例活动性RA患者和18例年龄及性别匹配的对照受试者进行了所有评估。与对照组相比，RA患者的血清MDA水平显著升高（p<0.03），而RA患者的总氧化状态水平低于对照组（p<0.008），两组之间血清SOD活性无统计学差异。总之，我们研究中MDA水平的升高作为一个标志物可能很重要，但不足以得出RA患者氧化应激增加的结论，因为从SOD和氧化状态测量中未获得支持性结果。这些结果进一步支持了氧自由基在慢性炎症性疾病发病机制中起作用的概念，但我们也认为存在比所设想的更复杂的关系。我们认为需要进一步研究来阐明这些相互矛盾的结果。
