Department of Pathophysiology, School of Basic Medical Science, Changsha Medical University, Changsha, 410219, People's Republic of China.
Department of Human Anatomy, Histology and Embryology, Institute of Neuroscience, Changsha Medical University, Changsha, 410219, People's Republic of China.
Inflamm Res. 2019 Apr;68(4):275-284. doi: 10.1007/s00011-019-01220-4. Epub 2019 Feb 23.
Both type 1 diabetes (T1D) and type 2 diabetes (T2D) are classified as forms of diabetes mellitus (DM) and commonly considered inflammatory process. Intercellular adhesion molecule-1 (ICAM-1) is involved in the development and progression of diabetes mellitus. However, the genetic association between ICAM-1 rs5498, and T1D and T2D risk was inconclusive.
A meta-analysis by searching the PubMed, Embase, Cochrane Library, and Chinese National Knowledge Infrastructure (CNKI) databases was performed out. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to describe the strength of association of T1D and T2D risk.
A total of 14 studies encompassing 3233 cases and 2884 controls were included in the present meta-analysis. Significant associations were found between the allele and recessive models of ICAM1 rs5498 and DM in Asian population (allele: OR 1.13; 95% CI 1.03-1.23, p = 0.008; recessive: OR 1.25; 95% CI 1.06-1.48, p = 0.008), but not in Caucasian population (p > 0.05). In addition, the allele model of rs5498 was found to be significantly associated with the increased risk of T2D (OR 1.10; 95% CI 1.01-1.21, p = 0.03), but not T1D (p > 0.05).
The ICAM1 rs5498 might be a susceptible factor for T2D, but not T1D. And the allele and recessive models of ICAM1 rs5498 might be a risk factor in Asian population.
1 型糖尿病（T1D）和 2 型糖尿病（T2D）均被归类为糖尿病（DM）的形式，通常被认为是炎症过程。细胞间黏附分子-1（ICAM-1）参与了糖尿病的发展和进展。然而，ICAM-1 rs5498 与 T1D 和 T2D 风险之间的遗传关联尚无定论。
通过搜索 PubMed、Embase、Cochrane 图书馆和中国国家知识基础设施（CNKI）数据库进行荟萃分析。采用合并优势比（OR）和 95%置信区间（CI）来描述 T1D 和 T2D 风险的关联强度。
本荟萃分析共纳入了 14 项研究，共纳入了 3233 例病例和 2884 例对照。在亚洲人群中，ICAM1 rs5498 的等位基因和隐性模型与 DM 存在显著相关性（等位基因：OR 1.13；95%CI 1.03-1.23，p=0.008；隐性：OR 1.25；95%CI 1.06-1.48，p=0.008），但在白种人群中无相关性（p>0.05）。此外，rs5498 的等位基因模型与 T2D 风险增加显著相关（OR 1.10；95%CI 1.01-1.21，p=0.03），但与 T1D 无关（p>0.05）。
ICAM1 rs5498 可能是 T2D 的易感因素，但不是 T1D 的易感因素。ICAM1 rs5498 的等位基因和隐性模型可能是亚洲人群的危险因素。
