• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

ICAM1 基因 E469K 多态性与糖尿病肾病风险的关联：一项荟萃分析。

Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis.

机构信息

Department of Pharmacy, Shenzhen Hospital, Southern Medical University, Shenzhen, 518000, Guangdong, China.

Department of Nephrology, The Eight Affiliated Hospital, SUNYAT-SEN University, Shenzhen, Guangzhou, 518033, China.

出版信息

Lipids Health Dis. 2018 Dec 26;17(1):293. doi: 10.1186/s12944-018-0922-2.

DOI:10.1186/s12944-018-0922-2
PMID:30587209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6307272/
Abstract

BACKGROUND

Inflammation may be a key pathophysiological mechanism in diabetic nephropathy (DN). Intercellular adhesion molecule 1 (ICAM1) is an acute phase marker of inflammation. ICAM1 rs5498 has been reported to be associated with the risk of DN. However, the previous findings were conflicting due to the limited sample sizes, different methodologies and ethnicities. Therefore, this study aimed to investigate the genetic association between ICAM1 rs5498 and the risk of DN.

METHODS

Two investigators independently searched the studies from the databases PubMed, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Embase. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the associations.

RESULTS

No significant association was detected between ICAM1 rs5498 and DN susceptibility in allelic and recessive models (p > 0.05). However, significant reduction of frequencies of the dominant model of ICAM1 rs5498 was only detected in the Caucasian subgroup (OR = 0.80; 95% CI = [0.65, 0.99], p = 0.04) and type 1 diabetes mellitus subgroup (OR = 0.80; 95% CI = [0.65, 0.99], p = 0.04).

CONCLUSIONS

Thus, ICAM1 rs5498 might be a risk factor for DN in Caucasians and type 1 diabetes mellitus patients, which suggested that ICAM1 rs5498 might help in early diagnosis and prevention of this disease. Further studies were needed to clarify the biochemical function and pathological role of ICAM1 rs5498 in the risk of DN.

摘要

背景

炎症可能是糖尿病肾病（DN）的关键病理生理机制。细胞间黏附分子 1（ICAM1）是炎症的急性期标志物。已有报道称，ICAM1 rs5498 与 DN 的风险相关。然而，由于样本量有限、方法学和种族不同，先前的研究结果存在争议。因此，本研究旨在探讨 ICAM1 rs5498 与 DN 风险之间的遗传关联。

方法

两名研究员独立从 PubMed、Web of Science、Cochrane 图书馆、中国知网（CNKI）和 Embase 数据库中检索研究。使用合并的优势比（OR）及其 95%置信区间（CI）来评估关联。

结果

在等位基因和隐性模型中，ICAM1 rs5498 与 DN 易感性之间未检测到显著关联（p>0.05）。然而，仅在白人群体亚组（OR=0.80；95%CI=[0.65, 0.99]，p=0.04）和 1 型糖尿病亚组（OR=0.80；95%CI=[0.65, 0.99]，p=0.04）中检测到 ICAM1 rs5498 显性模型的频率显著降低。

结论

因此，ICAM1 rs5498 可能是白人和 1 型糖尿病患者发生 DN 的危险因素，这表明 ICAM1 rs5498 可能有助于该疾病的早期诊断和预防。需要进一步的研究来阐明 ICAM1 rs5498 在 DN 风险中的生化功能和病理作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/7a24b2998dc7/12944_2018_922_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/8c56f44deec4/12944_2018_922_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/0260db4c1ab0/12944_2018_922_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/3c8e0cbb9776/12944_2018_922_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/7a24b2998dc7/12944_2018_922_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/8c56f44deec4/12944_2018_922_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/0260db4c1ab0/12944_2018_922_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/3c8e0cbb9776/12944_2018_922_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b06/6307272/7a24b2998dc7/12944_2018_922_Fig4_HTML.jpg

相似文献

1
Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis.ICAM1 基因 E469K 多态性与糖尿病肾病风险的关联：一项荟萃分析。
Lipids Health Dis. 2018 Dec 26;17(1):293. doi: 10.1186/s12944-018-0922-2.
2
Genetic, epigenetic and protein analyses of intercellular adhesion molecule 1 in Malaysian subjects with type 2 diabetes and diabetic nephropathy.马来西亚2型糖尿病和糖尿病肾病患者细胞间粘附分子1的基因、表观遗传和蛋白质分析。
J Diabetes Complications. 2015 Nov-Dec;29(8):1234-9. doi: 10.1016/j.jdiacomp.2015.07.004. Epub 2015 Jul 22.
3
Evaluation of the association between the common E469K polymorphism in the ICAM-1 gene and diabetic nephropathy among type 1 diabetic patients in GoKinD population.GoKinD人群中1型糖尿病患者ICAM-1基因常见E469K多态性与糖尿病肾病之间关联的评估。
BMC Med Genet. 2008 May 27;9:47. doi: 10.1186/1471-2350-9-47.
4
The influence of ICAM1 rs5498 on diabetes mellitus risk: evidence from a meta-analysis.ICAM1 rs5498 对糖尿病风险的影响：荟萃分析证据。
Inflamm Res. 2019 Apr;68(4):275-284. doi: 10.1007/s00011-019-01220-4. Epub 2019 Feb 23.
5
Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease.ICAM-1 E469K 多态性对糖尿病肾病的遗传和生物学效应。
J Diabetes Res. 2020 Jun 12;2020:8305460. doi: 10.1155/2020/8305460. eCollection 2020.
6
Association between diabetic retinopathy in type 2 diabetes and the ICAM-1 rs5498 polymorphism: a meta-analysis of case-control studies.2型糖尿病患者糖尿病视网膜病变与细胞间黏附分子-1基因rs5498多态性的关联：病例对照研究的荟萃分析
BMC Ophthalmol. 2018 Nov 12;18(1):297. doi: 10.1186/s12886-018-0961-5.
7
Genetic influences of the intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in development of Type 1 diabetes and diabetic nephropathy.细胞间黏附分子1（ICAM-1）基因多态性对1型糖尿病及糖尿病肾病发生发展的遗传影响。
Diabet Med. 2006 Oct;23(10):1093-9. doi: 10.1111/j.1464-5491.2006.01948.x.
8
Association between intercellular adhesion molecule 1 (ICAM1) polymorphisms and diabetic foot susceptibility: A case-control study.细胞间黏附分子1（ICAM1）基因多态性与糖尿病足易感性的关联：一项病例对照研究。
Medicine (Baltimore). 2020 Mar;99(11):e18052. doi: 10.1097/MD.0000000000018052.
9
Intracellular adhesion molecule-1 K469E gene polymorphism and risk of diabetic microvascular complications: a meta-analysis.细胞间黏附分子-1 K469E 基因多态性与糖尿病微血管并发症风险的关系：一项荟萃分析。
PLoS One. 2013 Jul 26;8(7):e69940. doi: 10.1371/journal.pone.0069940. Print 2013.
10
Associations of intercellular adhesion molecule-1 rs5498 polymorphism with ischemic stroke: A meta-analysis.细胞间黏附分子-1 rs5498 多态性与缺血性脑卒中的关联：Meta 分析。
Mol Genet Genomic Med. 2019 Jun;7(6):e643. doi: 10.1002/mgg3.643. Epub 2019 Apr 17.

引用本文的文献

1
The beneficial effect of gamma aminobutyric acid on diabetic nephropathy in type 2 diabetic rat model and their offspring.γ-氨基丁酸对2型糖尿病大鼠模型及其子代糖尿病肾病的有益作用。
Res Pharm Sci. 2025 Aug 25;20(4):590-609. doi: 10.4103/RPS.RPS_94_24. eCollection 2025 Aug.
2
Associations of genetic factors with vascular diabetes complications: an umbrella review.遗传因素与血管性糖尿病并发症的关联：一项系统性综述
J Glob Health. 2025 Mar 21;15:04081. doi: 10.7189/jogh.15.04081.
3
Impact of magnesium sulfate therapy in improvement of renal functions in high fat diet-induced diabetic rats and their offspring.

本文引用的文献

1
Assessment of traditional knowledge of the antidiabetic plants of Darjeeling and Sikkim Himalayas in the context of recent phytochemical and pharmacological advances.评估达吉岭和锡金喜马拉雅山地区抗糖尿病植物的传统知识，结合近期植物化学和药理学进展。
J Integr Med. 2016 Sep;14(5):336-58. doi: 10.1016/S2095-4964(16)60267-4.
2
Need of integrated dietary therapy for persons with diabetes mellitus and "unhealthy" body constitution presentations.糖尿病患者及“偏颇”体质人群需要综合饮食疗法。
J Integr Med. 2016 Jul;14(4):255-68. doi: 10.1016/S2095-4964(16)60255-8.
3
Genetic, epigenetic and protein analyses of intercellular adhesion molecule 1 in Malaysian subjects with type 2 diabetes and diabetic nephropathy.
硫酸镁治疗对高脂肪饮食诱导的糖尿病大鼠及其子代肾功能改善的影响。
Sci Rep. 2023 Feb 8;13(1):2273. doi: 10.1038/s41598-023-29540-w.
4
Machine learning-guided covariate selection for time-to-event models developed from a small sample of real-world patients receiving bevacizumab treatment.基于接受贝伐珠单抗治疗的真实世界小样本患者开发的生存数据模型的机器学习引导协变量选择。
CPT Pharmacometrics Syst Pharmacol. 2022 Oct;11(10):1328-1340. doi: 10.1002/psp4.12848. Epub 2022 Aug 4.
5
Lipid deposition and metaflammation in diabetic kidney disease.糖尿病肾病中的脂质沉积和代谢炎症。
Curr Opin Pharmacol. 2020 Dec;55:60-72. doi: 10.1016/j.coph.2020.09.004. Epub 2020 Nov 1.
6
Genetic and Biological Effects of ICAM-1 E469K Polymorphism in Diabetic Kidney Disease.ICAM-1 E469K 多态性对糖尿病肾病的遗传和生物学效应。
J Diabetes Res. 2020 Jun 12;2020:8305460. doi: 10.1155/2020/8305460. eCollection 2020.
7
Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy.靶向糖尿病肾病炎症的致病途径和治疗方法。
Int J Mol Sci. 2020 May 27;21(11):3798. doi: 10.3390/ijms21113798.
马来西亚2型糖尿病和糖尿病肾病患者细胞间粘附分子1的基因、表观遗传和蛋白质分析。
J Diabetes Complications. 2015 Nov-Dec;29(8):1234-9. doi: 10.1016/j.jdiacomp.2015.07.004. Epub 2015 Jul 22.
4
Genomic profiling of advanced-stage, metaplastic breast carcinoma by next-generation sequencing reveals frequent, targetable genomic abnormalities and potential new treatment options.通过下一代测序对晚期化生性乳腺癌进行基因组分析，发现了常见的、可靶向的基因组异常以及潜在的新治疗选择。
Arch Pathol Lab Med. 2015 May;139(5):642-9. doi: 10.5858/arpa.2014-0200-OA.
5
Diabetic nephropathy and inflammation.糖尿病肾病与炎症
World J Diabetes. 2014 Jun 15;5(3):393-8. doi: 10.4239/wjd.v5.i3.393.
6
The genetics of diabetic nephropathy.糖尿病肾病的遗传学。
Genes (Basel). 2013 Nov 5;4(4):596-619. doi: 10.3390/genes4040596.
7
Association between PRO12ALA polymorphism of the PPAR-γ2 gene and type 2 diabetes mellitus in Iranian patients.伊朗患者中PPAR-γ2基因PRO12ALA多态性与2型糖尿病的关联。
Indian J Hum Genet. 2013 Apr;19(2):239-44. doi: 10.4103/0971-6866.116126.
8
Reno-protective effect of NECA in diabetic nephropathy: implication of IL-18 and ICAM-1.NECA 在糖尿病肾病中的肾保护作用：IL-18 和 ICAM-1 的作用。
Eur Cytokine Netw. 2012 Jul-Sep;23(3):78-86. doi: 10.1684/ecn.2012.0309.
9
Diabetes pharmacotherapy in 2012: considerations in medication selection.2012 年糖尿病药物治疗：药物选择的考虑因素。
Postgrad Med. 2012 Jul;124(4):84-94. doi: 10.3810/pgm.2012.07.2571.
10
Insights into type 1 diabetes provided by genetic analyses.遗传分析提供的 1 型糖尿病见解。
Curr Opin Endocrinol Diabetes Obes. 2012 Aug;19(4):263-70. doi: 10.1097/MED.0b013e328355b7fe.