Tangkijvanich P, Theamboonlers A, Hirsch P, Thongngam D, Kullavanijaya P, Poovorawan Y
Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1999 Sep;30(3):489-95.
We have investigated several groups of Thai patients diagnosed with chronic liver disease including chronic hepatitis, cirrhosis and hepatocellular carcinoma, as well as cholangiocarcinoma, for the prevalence of infection with either one of the hepatitis viruses B, C, G and the novel hepatitis virus TT (TTV). The 168 patients tested comprised 120 men and 48 women with their median age ranging from 42.3 to 62.3 years. Screening for antibodies to HBV and HCV was performed by a commercially available serological test kit, for the presence of HBV and TTV DNA by PCR, and of HCV and HGV RNA by RT-PCR, respectively. There was a clear two-fold higher prevalence of HBV (49%) over HCV (27%) infection and a four-fold higher frequency compared to HGV (13%) and TTV (11%) infection, respectively, in those individuals with chronic hepatitis, cirrhosis, and hepatocellular carcinoma, whereas all but one patient with cholangiocarcinoma the etiology of which has been ascribed to parasitic infestation, were free of all viral markers. In Thailand chronic HBV, and to a lesser extent, chronic HCV infection represent the two most common causes of hepatitis potentially proceeding to chronic liver disease, whereas the clinical significance pertinent to HGV and TTV remains to be elucidated.
我们调查了几组被诊断患有慢性肝病的泰国患者，包括慢性肝炎、肝硬化、肝细胞癌以及胆管癌患者，以了解感染乙型肝炎病毒、丙型肝炎病毒、庚型肝炎病毒和新型肝炎病毒TT（TTV）的流行情况。接受检测的168名患者中，有120名男性和48名女性，年龄中位数在42.3岁至62.3岁之间。采用市售血清学检测试剂盒检测乙肝病毒（HBV）和丙肝病毒（HCV）抗体，分别通过聚合酶链反应（PCR）检测HBV和TTV DNA，通过逆转录聚合酶链反应（RT-PCR）检测HCV和HGV RNA。在慢性肝炎、肝硬化和肝细胞癌患者中，HBV感染率（49%）明显比HCV感染率（27%）高出两倍，分别比HGV（13%）和TTV（11%）感染率高出四倍。而除一名病因归因于寄生虫感染的胆管癌患者外，所有胆管癌患者均未检测到任何病毒标志物。在泰国，慢性HBV感染以及程度较轻的慢性HCV感染是可能发展为慢性肝病的两种最常见的肝炎病因，而HGV和TTV的临床意义仍有待阐明。
