Goldstein M A, Cheng J, Schroeter J P
Department of Medicine, Baylor College of Medicine, Houston, TX 77030-3498, USA.
Aviat Space Environ Med. 1998 Jun;69(6 Suppl):A12-6.
Our previous study of rats exposed for 14 d to microgravity on Cosmos 2044 revealed morphological changes consistent with cardiac atrophy.
In the current comparison study, light and electron microscopic studies were performed on cardiac muscle from 10 rats exposed to hypergravity (continuous centrifugation at 2G) for 14 d.
Myofiber area was significantly greater in the 2G papillary muscle as compared with muscle from 10 control rats of the same strain and size. This contrasts with the significant decrease in myofiber area previously seen in the rats exposed to microgravity. At the electron microscopic level, general morphological features were similar in both groups and resembled tissue from control rats from the previous Cosmos studies. However, mitochondria from papillary and ventricular muscle from the 2G rats revealed signs of fatigue typical of the early stage of hypertrophy. These results are consistent with a state of adaptive cardiac hypertrophy for the 2G group.
我们之前对在“宇宙2044”号上暴露于微重力环境14天的大鼠进行的研究显示，其形态变化与心脏萎缩一致。
在当前的比较研究中，对10只暴露于超重环境（2G连续离心）14天的大鼠的心肌进行了光镜和电镜研究。
与10只相同品系和大小的对照大鼠的肌肉相比，2G乳头肌中的肌纤维面积显著更大。这与之前在暴露于微重力环境的大鼠中观察到的肌纤维面积显著减少形成对比。在电子显微镜水平上，两组的一般形态特征相似，类似于之前“宇宙”研究中对照大鼠的组织。然而，2G大鼠乳头肌和心室肌中的线粒体显示出肥大早期典型的疲劳迹象。这些结果与2G组的适应性心脏肥大状态一致。
