Dorsch C A, White G M, Berzofsky R N
Am J Clin Pathol. 1979 Mar;71(3):333-7. doi: 10.1093/ajcp/71.3.333.
By the use of a combination of Ouchterlony immunodiffusion and hemagglutination, it was found that 30 of 81 sera (37%) from patients who had systemic lupus erythematosus (SLE) had antibodies to the ribonucleoprotein component of extractable nuclear antigen, and 37 (46%) had antibody to the Sm antigen. Immunodiffusion was more sensitive for detection of anti-ribonucleoprotein, while hemagglutination detected more anti-Sm. Both technics are necessary to define qualitatively the types of antibodies present in SLE sera.
通过使用双向免疫扩散和血凝反应相结合的方法，发现81例系统性红斑狼疮（SLE）患者中有30例（37%）血清含有可提取核抗原核糖核蛋白成分的抗体，37例（46%）含有抗Sm抗原的抗体。免疫扩散检测抗核糖核蛋白更敏感，而血凝反应检测到更多的抗Sm抗体。两种技术对于定性确定SLE血清中存在的抗体类型都是必需的。
