心肌梗死后缓激肽B1受体表达上调。
Upregulation of bradykinin B1-receptor expression after myocardial infarction.
作者信息
Tschöpe C, Heringer-Walther S, Koch M, Spillmann F, Wendorf M, Leitner E, Schultheiss H P, Walther T
机构信息
Department of Cardiology and Pneumology, University Hospital Benjamin Franklin, Free University of Berlin, Germany.
出版信息
Br J Pharmacol. 2000 Apr;129(8):1537-8. doi: 10.1038/sj.bjp.0703239.
Abstract
To determine the influence of the myocardial infarction (MI) on bradykinin B1-receptor (B1R) regulation, we studied its expression in the left ventricle (LV) after MI. Rats were submitted to a permanent occlusion of the left coronary artery. Six hours, 24 h and 6 days after MI or after sham operation, left ventricular pressure (LVP) and dP/dt(max) were measured. LV-total RNA was extracted and B1R expression was analysed by a RNase-protection assay (each group n = 6). LVP and dP/dt(max) were impaired at all time points after MI. Basal B1R expression was not detectable in controls. Six hours after MI, the B1R expression was upregulated and reached a maximum 24 h after MI (4 fold vs. 6 h). Six days post-MI, B1R expression returned to levels found 6 h after MI. These data are the first demonstration for an induced myocardial B1R expression in an in vivo model of MI.
摘要
为了确定心肌梗死（MI）对缓激肽B1受体（B1R）调节的影响，我们研究了MI后左心室（LV）中B1R的表达。将大鼠的左冠状动脉进行永久性结扎。在MI后6小时、24小时和6天或假手术后，测量左心室压力（LVP）和dP/dt（max）。提取LV总RNA，并通过核糖核酸酶保护分析（每组n = 6）分析B1R表达。MI后所有时间点的LVP和dP/dt（max）均受损。在对照组中未检测到基础B1R表达。MI后6小时，B1R表达上调，并在MI后24小时达到最大值（与6小时相比增加4倍）。MI后6天，B1R表达恢复到MI后6小时的水平。这些数据首次证明了在MI体内模型中诱导心肌B1R表达。
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