酵母中的磷酸肌醇信号传导与膜运输调控

Phosphoinositide signaling and the regulation of membrane trafficking in yeast.

作者信息

Odorizzi G, Babst M, Emr S D

机构信息

Dept of Cellular and Molecular Medicine and Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093-0668, USA.

出版信息

Trends Biochem Sci. 2000 May;25(5):229-35. doi: 10.1016/s0968-0004(00)01543-7.

DOI:10.1016/s0968-0004(00)01543-7

PMID:10782093

Abstract

Phosphoinositides are key regulators of diverse cellular processes in eukaryotic cells. Genetic studies in yeast have advanced our understanding of how phosphoinositide-signaling pathways regulate membrane trafficking. Enzymes required for the synthesis (kinases) and turnover (phosphatases) of distinct phosphoinositides have been identified and several downstream effector molecules linked to phosphoinositide signaling have recently been characterized.

摘要

磷酸肌醇是真核细胞中多种细胞过程的关键调节因子。酵母中的遗传学研究加深了我们对磷酸肌醇信号通路如何调节膜运输的理解。不同磷酸肌醇合成（激酶）和周转（磷酸酶）所需的酶已被鉴定出来，并且最近对几种与磷酸肌醇信号相关的下游效应分子进行了表征。