Lecomte J
Ann Anesthesiol Fr. 1976;17(3):347-53.
The authors studies the factors involved in the antigenicity of the principal medications used in anaesthetics, including general anaesthesia, local anaesthetics and muscle relaxants. Any attempt at establishing a correlation between the chemical properties of these medications and their haptenic power would seem difficult by virtue of the fact that the complications seen in clinical practice are characterised by their rarity. The latter may be explained either on the basis of a low haptenic power of the substances or by the fact of their administration which is rarely repeated after a short time interval. Finally, the difficulties of this correlation are even further increased by the fact that the haptenic power is not always due to the medication itself, but sometimes to one of its metabolites.
作者研究了麻醉中使用的主要药物的抗原性相关因素，包括全身麻醉药、局部麻醉药和肌肉松弛剂。鉴于临床实践中所见并发症的特点是罕见，要在这些药物的化学性质与其半抗原能力之间建立关联似乎很困难。后者可以基于物质的低半抗原能力来解释，或者基于其给药情况来解释，即在短时间间隔后很少重复给药。最后，由于半抗原能力并不总是归因于药物本身，有时归因于其代谢产物之一，这种关联的难度进一步增加。
