Sen L, Borella L
N Engl J Med. 1975 Apr 17;292(16):828-32. doi: 10.1056/NEJM197504172921604.
Of 48 children with acute lymphocytic leukemia 11 had blast cells with receptors for sheep erythrocytes in their initial bone-marrow aspirates and 37 did not. A comparison of selected clinical features indicated striking differences between the two groups. Leukemia with the receptors was associated with a high proportion of older children, predominantly boys, a thymic mass, and a high white-cell count at diagnosis. In contrast, the 37 children with leukemia without the receptors were generally less than five years of age, with a nearly equal distribution of boys and girls; all but one had normal chest roentgenograms, and only one had a white-cell count greater than 100,000. Thus, the presence or absence of lymphoblasts with sheep erythrocyte receptors--a T-cell marker--distinguishes two forms of childhood acute lymphocytic leukemia, each with a distinct distribution of age and sex as well as other characteristic clinical features.
在48例急性淋巴细胞白血病患儿中，11例在初次骨髓穿刺液中可见带有绵羊红细胞受体的原始细胞，37例则未见。对选定临床特征的比较显示，两组之间存在显著差异。带有受体的白血病与较大儿童（主要为男孩）的高比例、胸腺肿块以及诊断时的高白细胞计数相关。相比之下，37例无受体白血病患儿一般年龄小于5岁，男女孩分布几乎相等；除1例之外，所有人胸部X线片均正常，只有1例白细胞计数大于100,000。因此，带有绵羊红细胞受体的淋巴母细胞（一种T细胞标志物）的存在与否可区分两种儿童急性淋巴细胞白血病，每种白血病在年龄和性别分布以及其他特征性临床特征方面都有所不同。
