Rader D J, Jaye M
University of Pennsylvania School of Medicine, Department of Medicine, Philadelphia, USA.
Curr Opin Lipidol. 2000 Apr;11(2):141-7. doi: 10.1097/00041433-200004000-00006.
The triglyceride lipase gene family plays a central role in intestinal lipid absorption, energy homeostasis, lipoprotein metabolism, and atherosclerosis. A new member of this gene family, termed endothelial lipase, was recently reported. The presence of key functional motifs, the endothelial synthesis, the enzymatic profile, and the in-vivo metabolic effects of endothelial lipase suggest that, like other members of this gene family, endothelial lipase may play a role in energy delivery to tissues and in modulating lipoprotein metabolism, and could impact on atherogenesis.
甘油三酯脂肪酶基因家族在肠道脂质吸收、能量稳态、脂蛋白代谢和动脉粥样硬化中起着核心作用。最近报道了该基因家族的一个新成员，称为内皮脂肪酶。内皮脂肪酶关键功能基序的存在、内皮合成、酶学特征及体内代谢效应表明，与该基因家族的其他成员一样，内皮脂肪酶可能在向组织输送能量以及调节脂蛋白代谢中发挥作用，并可能影响动脉粥样硬化的发生发展。
