Remuzzi G, Livio M, Roncaglioni M C, Mecca G, Donati M B, de Gaetano G
Br Med J. 1977 Aug 6;2(6083):359-61. doi: 10.1136/bmj.2.6083.359.
Normal or increased concentrations of factor VIII procoagulant activity (VIIIC), factor VIII-related antigen (VIIIRA), and factor VIII-von Willebrand activity (VIIIVWF) were found in the predialysis plasma of 10 out of 11 patients with chronic renal failure (CRF). All patients had a bleeding time longer than 15 minutes and platelet retention to glass beads lower than 40%. The only patient who had reduced concentrations of all three factor VIII complex components was subsequently shown to have von Willebrand's disease. In four patients with CRF, very low platelet retention, and slightly prolonged bleeding time none of the three factor VIII COMPLEX COMPONENTS WERE SELECTIVely modified in predialysis samples. These findings suggest that the bleeding tendency common in CRF is not necessarily linked to defective plasma factor VIII-related activities.
在11例慢性肾衰竭（CRF）患者中，有10例患者的透析前血浆中发现因子VIII促凝血活性（VIIIC）、因子VIII相关抗原（VIIIRA）和因子VIII-血管性血友病因子活性（VIIIVWF）浓度正常或升高。所有患者的出血时间均超过15分钟，血小板对玻璃珠的黏附率低于40%。唯一一例三种因子VIII复合成分浓度均降低的患者随后被诊断为血管性血友病。在4例CRF患者中，血小板黏附率极低且出血时间稍有延长，其透析前样本中三种因子VIII复合成分均未发生选择性改变。这些发现表明，CRF中常见的出血倾向不一定与血浆中因子VIII相关活性缺陷有关。
