Grinshteĭn Iu I, Shestovitskiĭ V A, Kuligina-Maksimova A V, Cherkashina I I, Aristov A I
Klin Med (Mosk). 2003;81(7):28-31.
The study purpose was the cytooxidant properties of inflammation in patients with severe heterogenic forms of chronic obstructive pulmonary disease (COPD); and the informative value of the changes in the studied indices for assessment of anti-inflammatory efficiency of differential therapy. The cytological test (CT) and chemiluminescent biotesting of bronchial lavage (CB) obtained with fibrobronchoscopy were conducted in 155 patients with severe bronchial asthma and chronic obstructive bronchitis. The patients were divided into groups according to current classification and predominant etiological factor of the exacerbation. The data of CT and CB in exacerbation significantly differ from the findings in the control group. They also differed in bronchial asthma and chronic obstructive bronchitis. The differentiated treatment resulted in improvement but did not reach the parameters of the control group. Thus, changes in CT and CB proved to be of the differentiated nature and this enables to use the tests as additional sensitive examinations in clinical practice.
本研究目的是探讨重度异质性慢性阻塞性肺疾病（COPD）患者炎症的细胞氧化特性；以及所研究指标变化对评估差异治疗抗炎效果的信息价值。对155例重度支气管哮喘和慢性阻塞性支气管炎患者进行了纤维支气管镜检查获取的支气管灌洗（CB）的细胞学检测（CT）和化学发光生物检测。根据当前分类和加重的主要病因因素将患者分组。加重期的CT和CB数据与对照组的结果显著不同。支气管哮喘和慢性阻塞性支气管炎之间也存在差异。差异治疗使病情有所改善，但未达到对照组的参数。因此，CT和CB的变化证明具有差异性质，这使得这些检测能够在临床实践中用作额外的敏感检查。
