Rumi G, Szabó I, Vincze A, Matus Z, Tóth G, Mózsik G
First Department of Medicine, University Medical School of Pécs, Hungary.
J Physiol Paris. 2000 Mar-Apr;94(2):159-61. doi: 10.1016/s0928-4257(00)00159-5.
Crohn's disease (CD) is frequently complicated by various nutritional disturbances. Although it is important to correct these disturbances, the nutritional status of CD patients has been poorly documented, especially concerning vitamin status. The aims of this study were (a) to measure the serum concentrations of vitamin A and six other carotenoids (lutein, zeaxanthin, alpha-, beta-carotene, alpha-, beta-cryptoxanthin) in patients with CD and to compare them with those in healthy controls and (b) to follow the changes of serum carotenoid levels in CD patients during treatment. Twenty-eight patients with CD and 23 healthy persons were included in this study. The results of twelve patients were followed up through one year. The patients were free of any nutritional treatment. The serum concentrations of carotenoids were measured with high-pressure liquid chromatography (HPLC). The serum concentrations of five carotenoids were significantly lower in the patients than in the controls (vitamin A, zeaxanthin: P < 0.001; alpha-, beta-carotene: P < 0.01; lutein: P < 0.05). The carotenoid status of the followed patients advanced to the normal range, but this increase was not significant. These findings suggest that there is a deficiency of vitamin A and its provitamins in Crohn' s disease prior to treatment. However, because we did not evaluate the vitamin intake in this study, we could not conclude which of the factors--poor intake, increased requirement, or malabsorption--was more important in decreasing of carotenoid levels.
克罗恩病（CD）常并发各种营养紊乱。尽管纠正这些紊乱很重要，但CD患者的营养状况记录较少，尤其是关于维生素状况。本研究的目的是：（a）测量CD患者血清中维生素A和其他六种类胡萝卜素（叶黄素、玉米黄质、α-、β-胡萝卜素、α-、β-隐黄质）的浓度，并与健康对照组进行比较；（b）跟踪CD患者治疗期间血清类胡萝卜素水平的变化。本研究纳入了28例CD患者和23名健康人。对12例患者进行了为期一年的随访。患者未接受任何营养治疗。用高压液相色谱法（HPLC）测量类胡萝卜素的血清浓度。患者血清中五种类胡萝卜素的浓度显著低于对照组（维生素A、玉米黄质：P<0.001；α-、β-胡萝卜素：P<0.01；叶黄素：P<0.05）。随访患者的类胡萝卜素状况升至正常范围，但这种升高并不显著。这些发现表明，CD患者在治疗前存在维生素A及其维生素原缺乏。然而，由于本研究未评估维生素摄入量，我们无法确定在类胡萝卜素水平降低中，摄入不足、需求增加或吸收不良这几个因素中哪个更重要。
